Source:http://linkedlifedata.com/resource/pubmed/id/10201937
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0015127,
umls-concept:C0021311,
umls-concept:C0026565,
umls-concept:C0026809,
umls-concept:C0029974,
umls-concept:C0036319,
umls-concept:C0079189,
umls-concept:C0205178,
umls-concept:C0205216,
umls-concept:C0205217,
umls-concept:C0205250,
umls-concept:C0332307,
umls-concept:C0871261,
umls-concept:C1314792,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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| pubmed:issue |
7
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| pubmed:dateCreated |
1999-5-13
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| pubmed:abstractText |
The granuloma that surrounds the Schistosoma mansoni egg is the cause of pathology in murine schistosomiasis, and its formation is driven by egg Ag-stimulated type 1 and type 2 cytokines. To determine the role of egg-driven immune responses during schistosome infection we rendered CBA/Ca mice unresponsive to schistosome eggs by combined cyclophosphamide treatment and thymectomy. In the early acute stages of schistosome infection, egg-tolerized mice suffered high mortalities. Granuloma size and deposition of collagen in the liver were significantly reduced in egg-tolerized mice. Similarly, limited granuloma responses were detected in the intestines of these mice, and this was associated with a >90% reduction in egg excretion. Histologically, egg-tolerized mice had exacerbated hepatocyte damage, with extensive microvesicular steatosis. Elevated plasma transaminase levels confirmed the damage to hepatocytes. Infected egg-tolerized mice had impaired proliferation responses to egg Ag but intact responses to worm Ag. Tolerized mice had diminished Ab responses to egg Ag and had a type 1 cytokine isotype pattern to worm Ag, with elevated IgG2a and diminished IgG1 and IgE. Egg-tolerized mice failed to down-regulate type 1 cytokines that are normally elicited during early schistosome infection. Hepatic granuloma cells from egg-tolerized mice were also type 1 cytokine dominated, with elevated frequencies of Tc1/Th1 and reduced Tc2/Th2 cells. This study demonstrates that mice tolerized to schistosome eggs have elevated type 1 cytokine responses with diminished type 2 responses and reduced anti-egg Ab during schistosome infection, and these effects are detrimental to the host.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
162
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4122-32
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| pubmed:dateRevised |
2010-8-25
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| pubmed:meshHeading |
pubmed-meshheading:10201937-Animals,
pubmed-meshheading:10201937-Antigens, Helminth,
pubmed-meshheading:10201937-Cytokines,
pubmed-meshheading:10201937-Down-Regulation,
pubmed-meshheading:10201937-Female,
pubmed-meshheading:10201937-Granuloma,
pubmed-meshheading:10201937-Immune Tolerance,
pubmed-meshheading:10201937-Immunity, Cellular,
pubmed-meshheading:10201937-Immunoglobulins,
pubmed-meshheading:10201937-Liver Diseases, Parasitic,
pubmed-meshheading:10201937-Mice,
pubmed-meshheading:10201937-Mice, Inbred CBA,
pubmed-meshheading:10201937-Ovum,
pubmed-meshheading:10201937-Schistosoma mansoni,
pubmed-meshheading:10201937-Schistosomiasis mansoni,
pubmed-meshheading:10201937-Th1 Cells,
pubmed-meshheading:10201937-Th2 Cells
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| pubmed:year |
1999
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| pubmed:articleTitle |
Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection.
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| pubmed:affiliation |
Department of Pathology, University of Cambridge, United Kingdom. pgf@mole.bio.cam.ac.uk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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