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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1999-4-15
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pubmed:abstractText |
Thirty-two Sprague-Dawley rats were exposed for 6 h/d for 14 consecutive days to JP-4 jet fuel vapor (2 mg/L) or room air control conditions. Following a 14- or 60-d recovery period, rats completed a battery of 8 tests selected from the Navy Neurobehavioral Toxicity Assessment Battery (NTAB) to evaluate changes in performance capacity. Exposure to JP-4 vapor resulted in significant changes in neurobehavioral capacity on several tests that varied as a function of the duration of the recovery period. Rats were evaluated for major neurotransmitter and metabolite levels in five brain regions and in the blood serum. Levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were shown to be significantly elevated in several brain regions as well as in the blood serum in the vapor-exposed groups. Results of the rat study are compared to previously reported neurobehavioral evaluations of European manufacturing personnel exposed chronically to jet fuel vapor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1528-7394
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pubmed:author |
pubmed-author:EggersJJ,
pubmed-author:HulmeM EME,
pubmed-author:LeahyH FHF,
pubmed-author:MacMahonK LKL,
pubmed-author:McCoolCC,
pubmed-author:McInturfSS,
pubmed-author:NarayananLL,
pubmed-author:NordholmA FAF,
pubmed-author:RitchieG DGD,
pubmed-author:RossiJJ3rd,
pubmed-author:WolfeR ERE
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
471-99
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10201635-Adaptation, Ocular,
pubmed-meshheading:10201635-Animals,
pubmed-meshheading:10201635-Appetite Regulation,
pubmed-meshheading:10201635-Biological Markers,
pubmed-meshheading:10201635-Body Weight,
pubmed-meshheading:10201635-Brain,
pubmed-meshheading:10201635-Disease Models, Animal,
pubmed-meshheading:10201635-Environmental Exposure,
pubmed-meshheading:10201635-Hydrocarbons,
pubmed-meshheading:10201635-Hydroxyindoleacetic Acid,
pubmed-meshheading:10201635-Male,
pubmed-meshheading:10201635-Motor Activity,
pubmed-meshheading:10201635-Pain Threshold,
pubmed-meshheading:10201635-Physical Examination,
pubmed-meshheading:10201635-Rats,
pubmed-meshheading:10201635-Rats, Sprague-Dawley,
pubmed-meshheading:10201635-Serotonin,
pubmed-meshheading:10201635-Startle Reaction
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pubmed:year |
1999
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pubmed:articleTitle |
Repeated exposure of rats to JP-4 vapor induces changes in neurobehavioral capacity and 5-HT/5-HIAA levels.
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pubmed:affiliation |
Naval Health Research Institute Detachment-Toxicology, Wright-Patterson Air Force Base, Ohio, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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