| pubmed-article:10199616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C1706383 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C0085940 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10199616 | lifeskim:mentions | umls-concept:C1521805 | lld:lifeskim |
| pubmed-article:10199616 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10199616 | pubmed:dateCreated | 1999-7-7 | lld:pubmed |
| pubmed-article:10199616 | pubmed:abstractText | The impulse flow-dependent dopamine release in the striatum was acutely blocked by unilateral lesion of the medial forebrain bundle with 6-hydroxydopamine. Within 45 min this disruption reduced the striatal extracellular dopamine levels by 80% as determined by in vivo voltammetry. A strong induction of c-fos messenger RNA was detected in the ipsilateral dorsolateral striatum 75 min after 6-hydroxydopamine injection by in situ hybridization. Double labelling demonstrates that this induction was confined to neurons expressing the dopamine D2 receptor messenger RNA. At this time-point, there were no changes in the striatal levels of either tyrosine hydroxylase immunoreactivity or dopamine D2 receptor messenger RNA. The c-fos messenger RNA expression induced by acute 6-hydroxydopamine injection was abolished by intraperitoneal pretreatment with the dopamine D2 receptor agonist, quinelorane (2 mg/kg) and strongly reduced by administration of the selective adenosine A2A receptor antagonist SCH-58261 (5 mg/kg). The results reported here show, by using a novel methodological approach, that an acute decrease of dopamine release causes an induction of c-fos messenger RNA in dopamine D2 receptor-containing striatopallidal neurons. This, together with previous findings, demonstrates that the c-fos gene expression is tonically inhibited by the impulse flow-dependent dopamine release via D2 receptors. In addition, this study provides evidence that endogenous adenosine, acting via adenosine A2A receptors, induces striatal c-fos messenger RNA when extracellular dopamine levels are strongly reduced. Thus endogenous dopamine and adenosine exert opposite effects on the activity of the D2-containing striatopallidal neurons. | lld:pubmed |
| pubmed-article:10199616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10199616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10199616 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10199616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10199616 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10199616 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:10199616 | pubmed:author | pubmed-author:FredholmB BBB | lld:pubmed |
| pubmed-article:10199616 | pubmed:author | pubmed-author:BlochBB | lld:pubmed |
| pubmed-article:10199616 | pubmed:author | pubmed-author:GonorJJ | lld:pubmed |
| pubmed-article:10199616 | pubmed:author | pubmed-author:Le MoineCC | lld:pubmed |
| pubmed-article:10199616 | pubmed:author | pubmed-author:SvenningssonP... | lld:pubmed |
| pubmed-article:10199616 | pubmed:author | pubmed-author:FourreauLL | lld:pubmed |
| pubmed-article:10199616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10199616 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:10199616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10199616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10199616 | pubmed:pagination | 827-37 | lld:pubmed |
| pubmed-article:10199616 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10199616 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10199616 | pubmed:articleTitle | Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons. | lld:pubmed |
| pubmed-article:10199616 | pubmed:affiliation | Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:10199616 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10199616 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10199616 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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