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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-7-7
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pubmed:abstractText |
The impulse flow-dependent dopamine release in the striatum was acutely blocked by unilateral lesion of the medial forebrain bundle with 6-hydroxydopamine. Within 45 min this disruption reduced the striatal extracellular dopamine levels by 80% as determined by in vivo voltammetry. A strong induction of c-fos messenger RNA was detected in the ipsilateral dorsolateral striatum 75 min after 6-hydroxydopamine injection by in situ hybridization. Double labelling demonstrates that this induction was confined to neurons expressing the dopamine D2 receptor messenger RNA. At this time-point, there were no changes in the striatal levels of either tyrosine hydroxylase immunoreactivity or dopamine D2 receptor messenger RNA. The c-fos messenger RNA expression induced by acute 6-hydroxydopamine injection was abolished by intraperitoneal pretreatment with the dopamine D2 receptor agonist, quinelorane (2 mg/kg) and strongly reduced by administration of the selective adenosine A2A receptor antagonist SCH-58261 (5 mg/kg). The results reported here show, by using a novel methodological approach, that an acute decrease of dopamine release causes an induction of c-fos messenger RNA in dopamine D2 receptor-containing striatopallidal neurons. This, together with previous findings, demonstrates that the c-fos gene expression is tonically inhibited by the impulse flow-dependent dopamine release via D2 receptors. In addition, this study provides evidence that endogenous adenosine, acting via adenosine A2A receptors, induces striatal c-fos messenger RNA when extracellular dopamine levels are strongly reduced. Thus endogenous dopamine and adenosine exert opposite effects on the activity of the D2-containing striatopallidal neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-amino-7-(2-phenylethyl)-2-(2-furyl...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P1 Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/quinelorane
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0306-4522
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
827-37
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10199616-Adenosine,
pubmed-meshheading:10199616-Animals,
pubmed-meshheading:10199616-Antiparkinson Agents,
pubmed-meshheading:10199616-Corpus Striatum,
pubmed-meshheading:10199616-Dopamine,
pubmed-meshheading:10199616-Dopamine Agonists,
pubmed-meshheading:10199616-Drug Design,
pubmed-meshheading:10199616-Gene Expression Regulation,
pubmed-meshheading:10199616-Genes, fos,
pubmed-meshheading:10199616-Globus Pallidus,
pubmed-meshheading:10199616-In Situ Hybridization,
pubmed-meshheading:10199616-Male,
pubmed-meshheading:10199616-Models, Neurological,
pubmed-meshheading:10199616-Nerve Tissue Proteins,
pubmed-meshheading:10199616-Neurons,
pubmed-meshheading:10199616-Oxidopamine,
pubmed-meshheading:10199616-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:10199616-Purinergic P1 Receptor Antagonists,
pubmed-meshheading:10199616-Pyrimidines,
pubmed-meshheading:10199616-Quinolines,
pubmed-meshheading:10199616-RNA, Messenger,
pubmed-meshheading:10199616-Rats,
pubmed-meshheading:10199616-Rats, Wistar,
pubmed-meshheading:10199616-Receptor, Adenosine A2A,
pubmed-meshheading:10199616-Receptors, Dopamine D2,
pubmed-meshheading:10199616-Triazoles,
pubmed-meshheading:10199616-Tyrosine 3-Monooxygenase
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pubmed:year |
1999
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pubmed:articleTitle |
Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons.
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pubmed:affiliation |
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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