rdf:type |
|
lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0017262,
umls-concept:C0017668,
umls-concept:C0028128,
umls-concept:C0030705,
umls-concept:C0033268,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0034897,
umls-concept:C0040732,
umls-concept:C0175630,
umls-concept:C0185117,
umls-concept:C0227651,
umls-concept:C1521761,
umls-concept:C1533698,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
1999-5-3
|
pubmed:abstractText |
Primary focal segmental glomerulosclerosis (FSGS) recurs in nearly 30% of patients who progress to end-stage renal disease and then receive a kidney transplant. A circulating plasma factor has been isolated from these patients that increases glomerular permeability to albumin in vitro. Because of the pivotal role of the mesangial cell in the accumulation of extracellular matrix (ECM) material within the glomerulus and the modulation of matrix protein synthesis by nitric oxide (NO), we examined the effect of the FSGS factor on inducible nitric oxide synthase (iNOS) expression and NO production by cultured rat mesangial cells (RMC).
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1081-5589
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-20
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:10198566-Animals,
pubmed-meshheading:10198566-Blood Proteins,
pubmed-meshheading:10198566-Cell Survival,
pubmed-meshheading:10198566-Cells, Cultured,
pubmed-meshheading:10198566-Cyclosporine,
pubmed-meshheading:10198566-Glomerular Mesangium,
pubmed-meshheading:10198566-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:10198566-Humans,
pubmed-meshheading:10198566-Indomethacin,
pubmed-meshheading:10198566-Kidney Transplantation,
pubmed-meshheading:10198566-Nitric Oxide,
pubmed-meshheading:10198566-Nitric Oxide Synthase,
pubmed-meshheading:10198566-Nitric Oxide Synthase Type II,
pubmed-meshheading:10198566-Plasmapheresis,
pubmed-meshheading:10198566-RNA, Messenger,
pubmed-meshheading:10198566-Rats,
pubmed-meshheading:10198566-Recurrence
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pubmed:year |
1999
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pubmed:articleTitle |
Circulating factor in patients with recurrent focal segmental glomerulosclerosis postrenal transplantation inhibits expression of inducible nitric oxide synthase and nitric oxide production by cultured rat mesangial cells.
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pubmed:affiliation |
Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, NY 11040-1432, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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