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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-5-6
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pubmed:databankReference |
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pubmed:abstractText |
We have recently identified the HMG box transcription factor Sox-13 and described its expression during murine embryogenesis. Here we describe the structure of the murine Sox-13 gene. This gene spans approximately 12 kb and consists of 13 exons. The HMG domain is encoded by exons XI and XII, separated by an intron that is conserved among Sox-5, Sox-13, and Sox-17. A single major transcription initiation site was identified. Deletion analysis of the 3-kb promoter region revealed a 400-bp fragment driving transcription of a luciferase reporter in a Sox-13-expressing cell line. To determine the chromosomal localization of the human gene, a human SOX13 cDNA was isolated with 75% homology to the mouse Sox-13. FISH analysis mapped the human SOX13 gene to chromosome 1 band q32.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10198172-Amino Acid Sequence,
pubmed-meshheading:10198172-Animals,
pubmed-meshheading:10198172-Autoantigens,
pubmed-meshheading:10198172-Base Sequence,
pubmed-meshheading:10198172-Blotting, Northern,
pubmed-meshheading:10198172-Cell Line,
pubmed-meshheading:10198172-Chromosome Mapping,
pubmed-meshheading:10198172-Chromosomes, Human, Pair 1,
pubmed-meshheading:10198172-DNA,
pubmed-meshheading:10198172-Exons,
pubmed-meshheading:10198172-Gene Expression Regulation,
pubmed-meshheading:10198172-High Mobility Group Proteins,
pubmed-meshheading:10198172-Humans,
pubmed-meshheading:10198172-In Situ Hybridization, Fluorescence,
pubmed-meshheading:10198172-Introns,
pubmed-meshheading:10198172-Luciferases,
pubmed-meshheading:10198172-Mice,
pubmed-meshheading:10198172-Molecular Sequence Data,
pubmed-meshheading:10198172-Promoter Regions, Genetic,
pubmed-meshheading:10198172-RNA,
pubmed-meshheading:10198172-Recombinant Fusion Proteins,
pubmed-meshheading:10198172-SOXD Transcription Factors,
pubmed-meshheading:10198172-Sequence Analysis, DNA,
pubmed-meshheading:10198172-Tissue Distribution
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pubmed:year |
1999
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pubmed:articleTitle |
The Sox-13 gene: structure, promoter characterization, and chromosomal localization.
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pubmed:affiliation |
Department of Immunology, University Hospital Utrecht, Utrecht, 3508 GA, The Netherlands. J.Roose@lab.azu.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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