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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-6-10
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pubmed:databankReference |
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pubmed:abstractText |
The N-terminal pyroglutamyl (pGlu) residue of peptide hormones, such as thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH), confers resistance to proteolysis by conventional aminopeptidases. Specialized pyroglutamyl peptidases (PGPs) are able to cleave an N-terminal pyroglutamyl residue and thus control hormonal signals. Until now, no direct or homology-based three-dimensional structure was available for any PGP.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0969-2126
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
399-411
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10196127-Amino Acid Sequence,
pubmed-meshheading:10196127-Bacillus,
pubmed-meshheading:10196127-Bacterial Proteins,
pubmed-meshheading:10196127-Binding Sites,
pubmed-meshheading:10196127-Biopolymers,
pubmed-meshheading:10196127-Catalytic Domain,
pubmed-meshheading:10196127-Crystallography, X-Ray,
pubmed-meshheading:10196127-Cysteine Endopeptidases,
pubmed-meshheading:10196127-Models, Molecular,
pubmed-meshheading:10196127-Molecular Sequence Data,
pubmed-meshheading:10196127-Protein Conformation,
pubmed-meshheading:10196127-Pyroglutamyl-Peptidase I,
pubmed-meshheading:10196127-Sequence Alignment,
pubmed-meshheading:10196127-Sequence Homology, Amino Acid,
pubmed-meshheading:10196127-Structure-Activity Relationship
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pubmed:year |
1999
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pubmed:articleTitle |
The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease.
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pubmed:affiliation |
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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