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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-6-10
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pubmed:databankReference |
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pubmed:abstractText |
T cells and natural killer (NK) cells perform complementary roles in the cellular immune system. T cells identify infected cells directly through recognition of antigenic peptides that are displayed at the target cell surface by the classical major histocompatibility complex (MHC) class I molecules. NK cells monitor the target cell surface for malfunction of this display system, lysing potentially infected cells that might otherwise evade recognition by the T cells. Human killer cell inhibitory receptors (KIRs) control this process by either inhibiting or activating the cytotoxic activity of NK cells via specific binding to MHC class I molecules on the target cell.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C*03 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/KIR2DL3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL3
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
391-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10196125-Amino Acid Sequence,
pubmed-meshheading:10196125-Cell Adhesion Molecules,
pubmed-meshheading:10196125-Crystallography, X-Ray,
pubmed-meshheading:10196125-HLA-C Antigens,
pubmed-meshheading:10196125-Humans,
pubmed-meshheading:10196125-Hydrogen Bonding,
pubmed-meshheading:10196125-Killer Cells, Natural,
pubmed-meshheading:10196125-Models, Molecular,
pubmed-meshheading:10196125-Molecular Sequence Data,
pubmed-meshheading:10196125-Protein Binding,
pubmed-meshheading:10196125-Protein Conformation,
pubmed-meshheading:10196125-Receptors, Immunologic,
pubmed-meshheading:10196125-Receptors, KIR,
pubmed-meshheading:10196125-Receptors, KIR2DL1,
pubmed-meshheading:10196125-Receptors, KIR2DL3,
pubmed-meshheading:10196125-Sequence Alignment,
pubmed-meshheading:10196125-Sequence Homology, Amino Acid,
pubmed-meshheading:10196125-Structure-Activity Relationship,
pubmed-meshheading:10196125-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.
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pubmed:affiliation |
Laboratory of Molecular Biophysics, Rex Richards Building, South Parks Road, Oxford OX1 3QU, UK. katsumi@biop.ox.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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