Source:http://linkedlifedata.com/resource/pubmed/id/10195753
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-7-16
|
| pubmed:abstractText |
New therapeutic regimens have dramatically altered morbidity and mortality attributed to HIV-1 infection. Changes in lymphocyte subsets after treatment may mirror salutary clinical changes. Over 4 months we analyzed lymphocyte subsets in 20 patients starting new HIV-1 therapy. Absolute numbers of lymphocytes, CD4+ T cells, CD8+ T cells, and B cells increased significantly by 4 months, but CD8+ T cell and B cell increases were restricted to late-stage patients. Subset analysis revealed that the magnitude of recovering naive-phenotype CD4+ T cells (slope) correlated with the number of these cells present at baseline, equaling or exceeding the memory-phenotype slope within days if these naive cells were abundant at baseline. Five of 10 patients in whom naive-phenotype CD4+ T cells were absent at baseline partially repopulated these cells by 4 months. These findings have important implications for the origin and mechanisms of renewal of naive-phenotype CD4+ T cells following effective treatment for HIV-1 infection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0889-2229
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
435-43
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10195753-Adult,
pubmed-meshheading:10195753-Anti-HIV Agents,
pubmed-meshheading:10195753-Antigens, CD45,
pubmed-meshheading:10195753-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10195753-Drug Therapy, Combination,
pubmed-meshheading:10195753-Female,
pubmed-meshheading:10195753-Flow Cytometry,
pubmed-meshheading:10195753-HIV Infections,
pubmed-meshheading:10195753-HIV-1,
pubmed-meshheading:10195753-Humans,
pubmed-meshheading:10195753-Immunologic Memory,
pubmed-meshheading:10195753-Immunophenotyping,
pubmed-meshheading:10195753-L-Selectin,
pubmed-meshheading:10195753-Lymphocyte Activation,
pubmed-meshheading:10195753-Male,
pubmed-meshheading:10195753-Middle Aged,
pubmed-meshheading:10195753-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:10195753-RNA, Viral,
pubmed-meshheading:10195753-T-Lymphocyte Subsets
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Lymphocyte kinetics and precursor frequency-dependent recovery of CD4(+)CD45RA(+)CD62L(+) naive T cells following triple-drug therapy for HIV type 1 infection.
|
| pubmed:affiliation |
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30333, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|