Linked Life Data

10194933

Source:http://linkedlifedata.com/resource/pubmed/id/10194933

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-5-4
pubmed:abstractText
SOS response in Escherichia coli is induced by various DNA-damaging treatments, for example by ultraviolet irradiation, to help a cell to recover from the damage. During induction of the SOS regulatory system, generation of the inducing signal for the system is the early step. In the present study a model for quantitative description of the signal dynamics is developed. We derive the inducing signal, in terms of concentration of single-stranded DNA, as a function of time since the moment of ultraviolet irradiation. Simulation of the signal level after irradiation with two doses of 5 and 20 J m-2 is presented. This provides quantitative description of the event that controls various cellular physiological reactions induced in the course of the SOS response. The dynamics of the signal level are then used as an input for a dynamical equation description of the SOS regulatory system that we proposed earlier. This allows for a quantitative analysis of the subsequent step in the SOS induction: cleavage of LexA protein, a negative regulator of the SOS system. The model is verified against available experimental data for LexA protein level in ultraviolet radiation-induced Escherichia coli cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0025-5564
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-86
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Dynamics of the inducing signal for the SOS regulatory system in Escherichia coli after ultraviolet irradiation.
pubmed:affiliation
Division of Radiation and Radiobiological Research, Joint Institute for Nuclear Research, Dubna, Moscow region, Russian Federation. saksenov@iname.com
pubmed:publicationType
Journal Article