Source:http://linkedlifedata.com/resource/pubmed/id/10194143
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 1
|
| pubmed:dateCreated |
1999-5-17
|
| pubmed:abstractText |
In 18 patients with chronic obstructive pulmonary disease intubated and mechanically ventilated, we prospectively randomized 200 micrograms fenoterol-80 micrograms ipratropium bromide (four puffs) from a metered-dose inhaler (MDI) versus 1.25 mg fenoterol-500 micrograms ipratropium bromide in 5 ml saline from a nebulizer (NEB). Respiratory mechanics were assessed before and 30 min after the end of each delivery by the rapid end-inspiratory airway occlusion technique. We did vary on single breaths the inflation flow (V) from 0.2 to 1.2 L. s-1, at constant inflation volume. The total respiratory resistance of the respiratory system (Rrs) was partitioned into airway (Rint,rs) and tissue (DeltaRrs) resistances. We found that Rrs was equivalently reduced, from 16.49 +/- 1.37 to 14.85 +/- 1.88 cm H2O. L-1. s with MDI (p < 0.05) and from 18.04 +/- 1.85 to 15.15 +/- 1.33 cm H2O. L-1. s with NEB (p < 0.01). Whereas the prevailing effect of MDI was to reduce Rint,rs, that of NEB was to decrease DeltaRrs. In addition, the V resistance of the respiratory system over the whole range of V was significantly affected by NEB but not by MDI.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aerosols,
http://linkedlifedata.com/resource/pubmed/chemical/Bronchodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Fenoterol,
http://linkedlifedata.com/resource/pubmed/chemical/Ipratropium,
http://linkedlifedata.com/resource/pubmed/chemical/fenoterol, ipratropium drug...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
159
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1036-42
|
| pubmed:dateRevised |
2010-7-15
|
| pubmed:meshHeading |
pubmed-meshheading:10194143-Administration, Inhalation,
pubmed-meshheading:10194143-Aerosols,
pubmed-meshheading:10194143-Aged,
pubmed-meshheading:10194143-Airway Resistance,
pubmed-meshheading:10194143-Bronchodilator Agents,
pubmed-meshheading:10194143-Cross-Over Studies,
pubmed-meshheading:10194143-Drug Combinations,
pubmed-meshheading:10194143-Female,
pubmed-meshheading:10194143-Fenoterol,
pubmed-meshheading:10194143-Humans,
pubmed-meshheading:10194143-Ipratropium,
pubmed-meshheading:10194143-Lung Diseases, Obstructive,
pubmed-meshheading:10194143-Male,
pubmed-meshheading:10194143-Nebulizers and Vaporizers,
pubmed-meshheading:10194143-Prospective Studies,
pubmed-meshheading:10194143-Respiration, Artificial,
pubmed-meshheading:10194143-Respiratory Insufficiency,
pubmed-meshheading:10194143-Single-Blind Method
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Inhaled fenoterol-ipratropium bromide in mechanically ventilated patients with chronic obstructive pulmonary disease.
|
| pubmed:affiliation |
Service de Réanimation Médicale, Centre Hospitalier Lyon-Sud, Pierre-Bénite, Service Central d'Explorations Fonctionnelles Respiratiores, Groupe Hospitalier Pitié-Salpétriére, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|