|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1999-4-21
|
|
pubmed:abstractText |
The predominant immunological finding in HIV+ haemophilia patients is a decrease of CD4+ lymphocytes during progression of the disease. Depletion of CD4+ lymphocytes is paralleled by an increase in the proportion of immune complex-coated CD4+ cells. We examined the hypothesis that the formation of immune complexes on CD4+ lymphocytes is followed by rapid clearance of immune complex-coated CD4+ lymphocytes from the circulation. In this study, the relationship of relative to absolute numbers of immune complex-loaded CD4+ blood lymphocytes and their association with viral load were studied. Two measurements of relative and absolute numbers of gp120-, IgG- and/or IgM-loaded CD4+ lymphocytes were analysed in HIV+ and HIV- haemophilia patients, with a median interval of approx. 3 years. Immune complexes on CD4+ lymphocytes were determined using double-fluorescence flow cytometry and whole blood samples. Viral load was assessed using NASBA and Nuclisens kits. Whereas the proportion of immune complex-coated CD4+ lymphocytes increased with progression of the disease, absolute numbers of immune complex-coated CD4+ lymphocytes in the blood were consistently low. Relative increases of immune complex-coated CD4+ blood lymphocytes were significantly associated with decreases of absolute numbers of circulating CD4+ lymphocytes. The gp120 load on CD4+ blood lymphocytes increased in parallel with the viral load in the blood. These results indicate that immune complex-coated CD4+ lymphocytes are rapidly cleared from the circulation, suggesting that CD4+ reactive autoantibodies and immune complexes are relevant factors in the pathogenesis of AIDS. Relative increases of immune complex-positive cells seem to be a consequence of both an increasing retroviral activity as well as a stronger loading with immune complexes of the reduced number of CD4+ cells remaining during the process of CD4 depletion. The two mechanisms seem to enhance each other and contribute to the progressive CD4 decrease during the course of the disease.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-1374580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-1531308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-1642003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-1735193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-1824617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-2329275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-2536767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-2575824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-2784732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-2833917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-3037522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7483489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7514053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7539892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7768037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7908473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7911492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-7957553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8095360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8096699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8102328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8103248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8235617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8240663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8249129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8286843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8393034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8464405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8603531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8609222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8630395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8638160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8652832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8757347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8781430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8801768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-8820268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-9182471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-9472657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-9475352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-9486102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-9649560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10193421-9660361
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0009-9104
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
115
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
477-84
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:10193421-Antigen-Antibody Complex,
pubmed-meshheading:10193421-Antigens, CD4,
pubmed-meshheading:10193421-CD4 Lymphocyte Count,
pubmed-meshheading:10193421-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10193421-Case-Control Studies,
pubmed-meshheading:10193421-HIV Infections,
pubmed-meshheading:10193421-HIV Seronegativity,
pubmed-meshheading:10193421-Hemophilia A,
pubmed-meshheading:10193421-Humans,
pubmed-meshheading:10193421-Lymphopenia,
pubmed-meshheading:10193421-Male,
pubmed-meshheading:10193421-Time Factors,
pubmed-meshheading:10193421-Viremia
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
CD4 depletion in HIV-infected haemophilia patients is associated with rapid clearance of immune complex-coated CD4+ lymphocytes.
|
|
pubmed:affiliation |
Department of Transplantation Immunology, University of Heidelberg, Germany. Volker_Daniel@UKL.uni-heidelberg.de
|
|
pubmed:publicationType |
Journal Article,
Case Reports
|
