Source:http://linkedlifedata.com/resource/pubmed/id/10192398
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-4-26
|
| pubmed:databankReference | |
| pubmed:abstractText |
Hemizygous cryptic deletions of the q11 band of human chromosome 22 have been associated with a number of psychiatric and behavioural phenotypes, including schizophrenia. Here we report the isolation and characterization of PRODH, a human homologue of Drosophila melanogaster sluggish-A (slgA), which encodes proline dehydrogenase responsible for the behavioural phenotype of the slgA mutant. PRODH is localized at chromosome 22q11 in a region deleted in some psychiatric patients. We also isolated the mouse homologue of slgA (Prodh), identified a mutation in this gene in the Pro/Re hyperprolinaemic mouse strain and found that these mice have a deficit in sensorimotor gating accompanied by regional neurochemical alterations in the brain. Sensorimotor gating is a neural filtering process that allows attention to be focused on a given stimulus, and is affected in patients with neuropsychiatric disorders. Furthermore, several lines of evidence suggest that proline may serve as a modulator of synaptic transmission in the mammalian brain. Our observations, in conjunction with the chromosomal location of PRODH, suggest a potential involvement of this gene in the 22q11-associated psychiatric and behavioural phenotypes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1061-4036
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
434-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10192398-Acoustic Stimulation,
pubmed-meshheading:10192398-Amino Acid Metabolism, Inborn Errors,
pubmed-meshheading:10192398-Amino Acid Sequence,
pubmed-meshheading:10192398-Animals,
pubmed-meshheading:10192398-Behavior, Animal,
pubmed-meshheading:10192398-Blotting, Northern,
pubmed-meshheading:10192398-Brain,
pubmed-meshheading:10192398-Chromosomes, Human, Pair 22,
pubmed-meshheading:10192398-Female,
pubmed-meshheading:10192398-Humans,
pubmed-meshheading:10192398-Insect Proteins,
pubmed-meshheading:10192398-Male,
pubmed-meshheading:10192398-Mice,
pubmed-meshheading:10192398-Mice, Mutant Strains,
pubmed-meshheading:10192398-Molecular Sequence Data,
pubmed-meshheading:10192398-Mutation,
pubmed-meshheading:10192398-Neurotransmitter Agents,
pubmed-meshheading:10192398-Proline,
pubmed-meshheading:10192398-Proline Oxidase,
pubmed-meshheading:10192398-Sequence Homology, Amino Acid,
pubmed-meshheading:10192398-Startle Reaction
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.
|
| pubmed:affiliation |
The Rockefeller University, New York, New York 10021, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|