Linked Life Data

1019180

Source:http://linkedlifedata.com/resource/pubmed/id/1019180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1977-4-25
pubmed:abstractText
The effects of intraperitoneal injections of increasing doses of d- and l-amphetamine on self-stimulation behaviour in dorsal and ventral hypothalamic areas, were studied in BALB/c Orl., DBA/2 Orl, and C57BL/6 Orl inbred mice. Both isomers improved and disrupted self-stimulation as a function of the doses injected. However, the improvements obtained with d-amphetamine were higher than those obtained with 1-amphetamine. In contrast the 1 isomer generally provoked the highest disruptions. In addition, the three strains presented various sensitivities to d-amphetamine, which improved self-stimulation first in BALB/c (0.25 and 0.50 mg/kg), then in DBA/2 (0.50 and 1.0 mg/kg) and finally in C57BL/6 (2.0, 4.0 and 8.0 mg/kg). The dorsal hypothalamic self-stimulation system presented a greater sensitivity to d-amphetamine than the ventral system; while the two reward systems reacted identically to 1-amphetamine. The differential effects observed are set into relationship with neurochemical data concerning the central catecholaminergic mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
505-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Effects of d- and l-amphetamine on dorsal and ventral hypothalamic self-stimulation in three inbred strains of mice.
pubmed:publicationType
Journal Article, Comparative Study