Source:http://linkedlifedata.com/resource/pubmed/id/10191769
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
1999-4-16
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| pubmed:abstractText |
Six patients with mantle cell lymphoma, blastoid variant, involving the blood are described. The circulating blast-like cells suggested the possibility of acute leukemias, chronic lymphoproliferative disorders or peripheralized lymphomas. The WBC counts ranged from 3,700 to 249,000/microL (3.7-249.0 x 10(9)/L) and the absolute lymphocyte counts from 1,000 to more than 200,000/microL (1.0 to > 200.0 x 10(9)/L). The peripheral blood smears showed a spectrum of cells, from small mature lymphocytes with irregular nuclei to medium-sized lymphocytes with blast-like chromatin. However, the morphologic features in a lymph node biopsy specimen and the immunophenotype confirmed a diagnosis of mantle cell lymphoma, blastoid variant. By flow cytometry the lymphoma cells expressed B-cell-associated antigens (CD19, CD20 and CD22), coexpressed CD5, lacked CD23, and expressed moderate intensity monoclonal surface immunoglobulin and CD20. Cytogenetic analysis showed the characteristic t(11;14) in 2 of 4 analyzed specimens. Mantle cell lymphoma, blastoid variant, is part of the differential diagnosis for blast-like cells.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
111
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
495-500
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10191769-Aged,
pubmed-meshheading:10191769-Antibodies, Monoclonal,
pubmed-meshheading:10191769-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:10191769-Bone Marrow Cells,
pubmed-meshheading:10191769-Cell Nucleus,
pubmed-meshheading:10191769-Chromatin,
pubmed-meshheading:10191769-Female,
pubmed-meshheading:10191769-Flow Cytometry,
pubmed-meshheading:10191769-Hepatomegaly,
pubmed-meshheading:10191769-Humans,
pubmed-meshheading:10191769-Immunophenotyping,
pubmed-meshheading:10191769-Leukocyte Count,
pubmed-meshheading:10191769-Lymph Nodes,
pubmed-meshheading:10191769-Lymphocyte Count,
pubmed-meshheading:10191769-Lymphocytes,
pubmed-meshheading:10191769-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10191769-Male,
pubmed-meshheading:10191769-Middle Aged,
pubmed-meshheading:10191769-Splenomegaly
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Leukemic phase of mantle cell lymphoma, blastoid variant.
|
| pubmed:affiliation |
Department of Pathology, University of Michigan Medical Center, Ann Arbor, USA.
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| pubmed:publicationType |
Journal Article
|