Source:http://linkedlifedata.com/resource/pubmed/id/10191767
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
1999-4-16
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| pubmed:abstractText |
We studied 40 patients with CD5- B-cell lymphoproliferative disorders (B-LPDs) presenting in blood or bone marrow and 28 control patients with CD5+ B-cell chronic lymphocytic leukemia (CLL). Fifteen study patients had morphologic features typical of CLL. The 15 patients with CD5- CLL were older and had lower absolute lymphocyte counts and more advanced-stage disease at diagnosis than controls. Ten study patients had morphologic features suggesting mantle cell lymphoma (MCL); 3 were later given a diagnosis of MCL based on lymph node biopsy results. The 10 patients with CD5- MCL were older and at a more advanced stage than CLL control patients. The remaining 15 study patients were given the following diagnoses: circulating non-Hodgkin lymphoma, 5; splenic lymphoma with villous lymphocytes, 5; lymphoplasmacytoid lymphoma, 3; and CLL/pro-lymphocytic leukemia, 2. For the patients with CD5- B-LPDs with morphologic features and manifestations resembling CLL, we prefer the term CD5- CLL variant because of clinical and immunophenotypic differences. Patients with CD5- B-LPDs with atypical nuclear morphologic features may represent the leukemic phase of MCL. Since CD23 is expressed in most patients with CD5- B-LPD, its use in subclassifying these disorders seems limited.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
111
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
477-87
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10191767-Adult,
pubmed-meshheading:10191767-Aged,
pubmed-meshheading:10191767-Aged, 80 and over,
pubmed-meshheading:10191767-Antigens, CD5,
pubmed-meshheading:10191767-B-Lymphocytes,
pubmed-meshheading:10191767-Biopsy,
pubmed-meshheading:10191767-Bone Marrow,
pubmed-meshheading:10191767-Female,
pubmed-meshheading:10191767-Flow Cytometry,
pubmed-meshheading:10191767-Humans,
pubmed-meshheading:10191767-Immunophenotyping,
pubmed-meshheading:10191767-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:10191767-Lymph Nodes,
pubmed-meshheading:10191767-Lymphocyte Count,
pubmed-meshheading:10191767-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10191767-Lymphoproliferative Disorders,
pubmed-meshheading:10191767-Male,
pubmed-meshheading:10191767-Middle Aged,
pubmed-meshheading:10191767-Receptors, IgE
|
| pubmed:year |
1999
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| pubmed:articleTitle |
CD5- B-cell lymphoproliferative disorders presenting in blood and bone marrow. A clinicopathologic study of 40 patients.
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| pubmed:affiliation |
Department of Pathology, Cleveland Clinic Foundation, Ohio 44195, USA.
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| pubmed:publicationType |
Journal Article
|