| pubmed-article:10191263 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C1539079 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10191263 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10191263 | pubmed:dateCreated | 1999-6-23 | lld:pubmed |
| pubmed-article:10191263 | pubmed:abstractText | 5-Hydroxytryptamine (5-HT, 'serotonin') is a potent inducer of the early response gene cyclo-oxygenase 2 (Cox-2; prostaglandin G/H synthase) in mesangial cells. Protein kinase C (PKC), Ca2+-dependent enzymes and mitogen-activated protein kinase (p42/44 MAPK) have previously been shown to be essential modules of the signalling pathway leading from the pertussis-insensitive 5-HT2A receptor to the induction of Cox-2 mRNA expression. In the present study, PKC activation was linked to the 5-HT-mediated phosphorylation and thus the activation of p42/44 MAPK: the inhibition of PKC by the specific inhibitor GF109203x prevented p42/44 MAPK activation. Ca2+/calmodulin-dependent (CaM) kinase II delta2 was detected in mesangial cells by Western blot analysis. The inhibition of CaM kinase by the inhibitors KN62 or KN93 led to a partial inhibition of 5-HT-induced Cox-2 mRNA expression and decreased basal, but not PMA-mediated, Cox-2 expression. The 5-HT-mediated activation of MAPK was not decreased by KN62 or KN93, excluding CaM kinase as a signalling module upstream of p42/44 MAPK. Taken together, these results indicate a modulatory involvement of CaM kinase in the regulation of 5-HT-mediated Cox-2 mRNA expression in addition to the main pathway that consists of the activation of PKC and p42/44 MAPK. | lld:pubmed |
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| pubmed-article:10191263 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10191263 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191263 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10191263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10191263 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10191263 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10191263 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:10191263 | pubmed:author | pubmed-author:HahnAA | lld:pubmed |
| pubmed-article:10191263 | pubmed:author | pubmed-author:Goppelt-Strue... | lld:pubmed |
| pubmed-article:10191263 | pubmed:author | pubmed-author:ReiserC OCO | lld:pubmed |
| pubmed-article:10191263 | pubmed:author | pubmed-author:StroebelMM | lld:pubmed |
| pubmed-article:10191263 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10191263 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10191263 | pubmed:volume | 339 ( Pt 2) | lld:pubmed |
| pubmed-article:10191263 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10191263 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10191263 | pubmed:pagination | 329-34 | lld:pubmed |
| pubmed-article:10191263 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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