| pubmed-article:10191214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0016627 | lld:lifeskim |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0019907 | lld:lifeskim |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:10191214 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:10191214 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10191214 | pubmed:dateCreated | 1999-6-7 | lld:pubmed |
| pubmed-article:10191214 | pubmed:abstractText | Recombinant reassortment technology was used to prepare H5N1 influenza vaccine strains containing a modified hemagglutinin (HA) gene and neuraminidase gene from the A/Hong Kong/156/97 and A/Hong Kong/483/97 isolates and the internal genes from the attenuated cold-adapted A/Ann Arbor/6/60 influenza virus strain. The HA cleavage site (HA1/HA2) of each H5N1 isolate was modified to resemble that of "low-pathogenic" avian strains. Five of 6 basic amino acids at the cleavage site were deleted, and a threonine was added upstream of the remaining arginine. The H5 HA cleavage site modification resulted in the expected trypsin-dependent phenotype without altering the antigenic character of the H5 HA molecule. The temperature-sensitive and cold-adapted phenotype of the attenuated parent virus was maintained in the recombinant strains, and they grew to 108.5-9.4 EID50/mL in eggs. Both H5N1 vaccine virus strains were safe and immunogenic in ferrets and protected chickens against wild-type H5N1 virus challenge. | lld:pubmed |
| pubmed-article:10191214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10191214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10191214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10191214 | pubmed:month | May | lld:pubmed |
| pubmed-article:10191214 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:LUGG | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:LisMM | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:PerdueM LML | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:SubbaraoKK | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:KlimovAA | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:HietalaSS | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:BryantMM | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:JOCC | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:WoodsLL | lld:pubmed |
| pubmed-article:10191214 | pubmed:author | pubmed-author:MuNN | lld:pubmed |
| pubmed-article:10191214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10191214 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:10191214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10191214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10191214 | pubmed:pagination | 1132-8 | lld:pubmed |
| pubmed-article:10191214 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:meshHeading | pubmed-meshheading:10191214... | lld:pubmed |
| pubmed-article:10191214 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10191214 | pubmed:articleTitle | Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses. | lld:pubmed |
| pubmed-article:10191214 | pubmed:affiliation | Aviron, Mountain View, California Veterinary Diagnostic Laboratory CA System, Davis, CA, USA. sli@aviron.com | lld:pubmed |
| pubmed-article:10191214 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10191214 | lld:pubmed |
