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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-6-23
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pubmed:abstractText |
Primary amyloidosis is a lethal form of plasma cell (PC) dyscrasia characterized by deposits of monoclonal immunoglobulin light chains that cause organ dysfunction. In contrast to multiple myeloma, the amyloid clone is typically indolent and of small size, and marrow PC clonality is not always apparent. This is generally investigated by analyzing the light chain isotype ratio in bone marrow PC. We investigated whether the degree of PC infiltration (PC%) and clonality (PC isotype ratio) affected survival in 56 consecutive patients with primary amyloidosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0390-6078
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-21
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10189385-Adult,
pubmed-meshheading:10189385-Aged,
pubmed-meshheading:10189385-Aged, 80 and over,
pubmed-meshheading:10189385-Amyloid,
pubmed-meshheading:10189385-Amyloidosis,
pubmed-meshheading:10189385-Bone Marrow,
pubmed-meshheading:10189385-Clone Cells,
pubmed-meshheading:10189385-Disease Progression,
pubmed-meshheading:10189385-Female,
pubmed-meshheading:10189385-Follow-Up Studies,
pubmed-meshheading:10189385-Gene Rearrangement, B-Lymphocyte, Light Chain,
pubmed-meshheading:10189385-Genes, Immunoglobulin,
pubmed-meshheading:10189385-Heart Failure,
pubmed-meshheading:10189385-Humans,
pubmed-meshheading:10189385-Immunoglobulin Light Chains,
pubmed-meshheading:10189385-Kidney Failure, Chronic,
pubmed-meshheading:10189385-Male,
pubmed-meshheading:10189385-Middle Aged,
pubmed-meshheading:10189385-Plasma Cells,
pubmed-meshheading:10189385-Prognosis,
pubmed-meshheading:10189385-Proportional Hazards Models,
pubmed-meshheading:10189385-Survival Analysis
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pubmed:year |
1999
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pubmed:articleTitle |
The degrees of plasma cell clonality and marrow infiltration adversely influence the prognosis of AL amyloidosis patients.
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pubmed:affiliation |
Biotechnology and Organ Transplantation Research Laboratories, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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