| pubmed-article:10189189 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10189189 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:10189189 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:10189189 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10189189 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:10189189 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10189189 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:10189189 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10189189 | pubmed:dateCreated | 1999-5-28 | lld:pubmed |
| pubmed-article:10189189 | pubmed:abstractText | Human (h) interleukin-10 (IL-10) exhibits a strong DNA and amino acid sequence homology to the Epstein-Barr virus (EBV) BCRF1 genome, viral (v) IL-10. We analyzed the production of IL-10 for EBV activation in B-cell lines. The latent EBV in Akata cells was activated by the cross-linking of surface immunoglobulin G (IgG) with anti-human IgG. The levels of IL-10(h+v) and vIL-10 in the culture fluids were measured by a specific enzyme-linked immunosorbent assay (ELISA). IL-10(h+v) was detected at the same time for EBV immediate early gene BZLF1 product ZEBRA and early gene BMRF1 product EA-D. This was more than 4 hours prior to the appearance of vIL-10, and late gene products gp 350/220 and viral capsid antigen. The induction of hIL-10 and vIL-10 mRNAs were detected in anti-IgG-treated Akata cells by reverse transcription-polymerase chain reaction. The induction of IL-10(h+v) and vIL-10 was inhibited with a tyrosine kinase inhibitor, herbimycin, or with an inhibitor of herpesvirus DNA polymerase, phosphonoacetic acid, or acyclovir. IL-10(h+v) and vIL-10 were also detected in the supernatants of Akata and Daudi but not Ramos cells infected with P3HR-1 EBV. These results show the IL-10 induction on EBV activation in EBV-carrying B-cell lines. | lld:pubmed |
| pubmed-article:10189189 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10189189 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10189189 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10189189 | pubmed:issn | 0882-8245 | lld:pubmed |
| pubmed-article:10189189 | pubmed:author | pubmed-author:OhnishiEE | lld:pubmed |
| pubmed-article:10189189 | pubmed:author | pubmed-author:KurataTT | lld:pubmed |
| pubmed-article:10189189 | pubmed:author | pubmed-author:InouyeSS | lld:pubmed |
| pubmed-article:10189189 | pubmed:author | pubmed-author:SairenjiTT | lld:pubmed |
| pubmed-article:10189189 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10189189 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10189189 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10189189 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10189189 | pubmed:pagination | 221-31 | lld:pubmed |
| pubmed-article:10189189 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
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| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
| pubmed-article:10189189 | pubmed:meshHeading | pubmed-meshheading:10189189... | lld:pubmed |
| pubmed-article:10189189 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:10189189 | pubmed:articleTitle | Induction of interleukin-10 on activation of Epstein-Barr virus in EBV-infected B-cell lines. | lld:pubmed |
| pubmed-article:10189189 | pubmed:affiliation | Department of Biosignaling, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan. | lld:pubmed |
| pubmed-article:10189189 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10189189 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
