Source:http://linkedlifedata.com/resource/pubmed/id/10189005
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-5-21
|
| pubmed:abstractText |
Beta-Blockers reduce mortality in patients with congestive heart failure and a proposed mechanism has been changes of autonomic tone. Heart rate variability is a non-invasive tool to estimate cardiac autonomic tone. The aim was to study changes of heart rate variability in patients with congestive heart failure on placebo, on the beta1-selective antagonist metoprolol or 24 h after metoprolol withdrawal. Forty-five patients with congestive heart failure were studied with Holter recordings. Heart rate variability measurements were performed before, after 6-12 months of treatment with 150 mg metoprolol/placebo, or 24 h after discontinued metoprolol. After treatment, patients on beta-blockade had a significantly longer mean RR interval and changes of heart rate variability, suggesting elevated vagal tone. Patients monitored in the rebound phase of beta-blocker withdrawal had a significant vagal reduction to the level of the placebo group. There was also a nonsignificant trend towards increased sympathetic tone (LF/HF over 24 h), compared with the beta-blockade group. Heart rate variability indicates an elevated vagal tone during treatment with metoprolol but beta-blockade withdrawal shifts the autonomic balance towards lower vagal and higher sympathetic tone within 24 h. These results could imply a potential risk when abruptly discontinuing beta-blockade medication in these patients.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
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| pubmed:issn |
0167-5273
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
28
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| pubmed:volume |
68
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
171-7
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10189005-Adolescent,
pubmed-meshheading:10189005-Adrenergic beta-Antagonists,
pubmed-meshheading:10189005-Adult,
pubmed-meshheading:10189005-Aged,
pubmed-meshheading:10189005-Electrocardiography, Ambulatory,
pubmed-meshheading:10189005-Female,
pubmed-meshheading:10189005-Follow-Up Studies,
pubmed-meshheading:10189005-Heart Failure,
pubmed-meshheading:10189005-Heart Rate,
pubmed-meshheading:10189005-Humans,
pubmed-meshheading:10189005-Male,
pubmed-meshheading:10189005-Metoprolol,
pubmed-meshheading:10189005-Middle Aged,
pubmed-meshheading:10189005-Myocardial Ischemia,
pubmed-meshheading:10189005-Prognosis,
pubmed-meshheading:10189005-Retrospective Studies,
pubmed-meshheading:10189005-Risk Factors,
pubmed-meshheading:10189005-Substance Withdrawal Syndrome,
pubmed-meshheading:10189005-Vagus Nerve,
pubmed-meshheading:10189005-Ventricular Fibrillation
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Potential risk of beta-blockade withdrawal in congestive heart failure due to abrupt autonomic changes.
|
| pubmed:affiliation |
Department of Medicine, Borås County Hospital, Sweden. hans.tygesen@mailbox.swipnet.se
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|