| pubmed-article:10188963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10188963 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:10188963 | lifeskim:mentions | umls-concept:C1868317 | lld:lifeskim |
| pubmed-article:10188963 | lifeskim:mentions | umls-concept:C0205332 | lld:lifeskim |
| pubmed-article:10188963 | lifeskim:mentions | umls-concept:C1152760 | lld:lifeskim |
| pubmed-article:10188963 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10188963 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10188963 | pubmed:dateCreated | 1999-5-27 | lld:pubmed |
| pubmed-article:10188963 | pubmed:abstractText | Excessive cyclo-oxygenase-2 (COX-2) induction may play a role in chronic neurological diseases characterized by inflammation and astrogliosis. We have previously identified an astroglial receptor for extracellular nucleotides, a P2Y receptor, whose stimulation leads to arachidonic acid (AA) release, followed, 3 days later, by morphological changes resembling reactive astrogliosis. Since COX-2 may be upregulated by AA metabolites, we assessed a possible role for COX-2 in P2Y receptor-mediated astrogliosis. A brief challenge of rat astrocytes with the ATP analogue alpha,beta-methylene ATP (alpha,beta(me)ATP) resulted, 24 h later, in significantly increased COX-2 expression. The selective COX-2 inhibitor NS-398 completely abolished alpha,beta(me)ATP-induced astrocytic activation. Constitutive astroglial COX-1 or COX-2 did not play any role in purine-induced reactive astrogliosis. PGE2, a main metabolite of COX-2, also induced astrocytic activation. These data suggest that a P2Y receptor mediates reactive astrogliosis via induction of COX-2. Antagonists selective for this receptor may counteract excessive COX-2 activation in both acute and chronic neurological diseases. | lld:pubmed |
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| pubmed-article:10188963 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10188963 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10188963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10188963 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10188963 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:10188963 | pubmed:author | pubmed-author:BurnstockGG | lld:pubmed |
| pubmed-article:10188963 | pubmed:author | pubmed-author:CattabeniFF | lld:pubmed |
| pubmed-article:10188963 | pubmed:author | pubmed-author:BrambillaRR | lld:pubmed |
| pubmed-article:10188963 | pubmed:author | pubmed-author:BonazziAA | lld:pubmed |
| pubmed-article:10188963 | pubmed:author | pubmed-author:AbbracchioM... | lld:pubmed |
| pubmed-article:10188963 | pubmed:author | pubmed-author:CerutiSS | lld:pubmed |
| pubmed-article:10188963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10188963 | pubmed:volume | 126 | lld:pubmed |
| pubmed-article:10188963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10188963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10188963 | pubmed:pagination | 563-7 | lld:pubmed |
| pubmed-article:10188963 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10188963 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10188963 | pubmed:articleTitle | Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis. | lld:pubmed |
| pubmed-article:10188963 | pubmed:affiliation | Institute of Pharmacological Sciences, University of Milan, Italy. | lld:pubmed |
| pubmed-article:10188963 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10188963 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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