Linked Life Data

10188909

Source:http://linkedlifedata.com/resource/pubmed/id/10188909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9-10
pubmed:dateCreated
1999-4-15
pubmed:abstractText
Ten consecutive patients with Hürthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hürthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hürthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hürthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-1337145, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-1346068, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-2261912, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-7630741, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-7738647, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-7799086, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-7953343, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-7978861, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-8373420, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-8483934, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-8683310, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-8813465, http://linkedlifedata.com/resource/pubmed/commentcorrection/10188909-9112914
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1579-82
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Expression of somatostatin receptors in oncocytic (Hürthle cell) neoplasia of the thyroid.
pubmed:affiliation
Department of Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't