Source:http://linkedlifedata.com/resource/pubmed/id/10188761
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-6-21
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pubmed:abstractText |
The chimaeric monoclonal antibody basiliximab specifically binds the alpha subunit of the interleukin-2 (IL-2) receptor on activated T lymphocytes. Through competitive antagonism of IL-2, basiliximab supplements standard immunosuppressive therapy after renal transplantation. < or =24 Hours after a single intravenous dose of basiliximab 2.5 to 25 mg, approximately 90% of available IL-2 receptors on T lymphocytes were complexed with the drug. This level of basiliximab binding was maintained for 4 to 6 weeks when renal transplant patients received basiliximab 20 mg 2 hours before and then 4 days after transplantation surgery. In 2 large, well-designed trials, the percentage of patients with biopsy-confirmed acute rejection episodes after renal transplantation was significantly lower with basiliximab 20 mg (administered 2 hours before and then 4 days after transplantation surgery; 30 or 33%, respectively) than placebo (44 or 46%) at 6 months after surgery. Basiliximab was well tolerated during clinical trials. The incidence of infections (including active cytomegalovirus infection) and post-transplant lymphoproliferative disorders was similar with basiliximab and placebo. Cytokine release syndrome was not observed in patients who received basiliximab.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/basiliximab
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0012-6667
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-13; discussion 214
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10188761-Animals,
pubmed-meshheading:10188761-Antibodies, Monoclonal,
pubmed-meshheading:10188761-Graft Rejection,
pubmed-meshheading:10188761-Humans,
pubmed-meshheading:10188761-Immunosuppressive Agents,
pubmed-meshheading:10188761-Interleukin-2,
pubmed-meshheading:10188761-Kidney Transplantation,
pubmed-meshheading:10188761-Mice,
pubmed-meshheading:10188761-Recombinant Fusion Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
Basiliximab.
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pubmed:affiliation |
Adis International Limited, Auckland, Mairangi Bay, New Zealand. demail@adis.co.nz
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pubmed:publicationType |
Journal Article,
Review
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