Linked Life Data

1016594

Source:http://linkedlifedata.com/resource/pubmed/id/1016594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1977-4-28
pubmed:abstractText
The acetylsalicylic acid, like other drugs with analogous properties, is an anti-inflammatory drug, whose mechanism of action is still unknown. Lymphocyte release, on stimulation, phlogogenic substances (lymphokines) which are responsible for some phlogistic processes, above all chronic. Acetylsalicylic acid inhibits some lymphocyte functions, therfore its mechanism of action may be possibly accounted for by this activity. This paper dealt with the effect observed that acetylsalicylic acid on mitogen-induced lymphocyte blastization. In vitro it was observed that acetylsalicylic acid inhibits blastization only when it is present in the incubation medium and that the inhibitor effect is dose dependent. In vivo, in the rat, it was observed that acetylsalicylic acid inhibits blastization only when administered some hours before lymphocyte withdrawal. The Authors believe that this effect may be accounted for by a metabolite of the drug itself.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-2547
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[Anti-inflammatory agents and lymphocytary reactivity].
pubmed:publicationType
Journal Article, English Abstract