Linked Life Data

10102069

Source:http://linkedlifedata.com/resource/pubmed/id/10102069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
428
pubmed:dateCreated
1999-5-27
pubmed:abstractText
Patients with hypochondroplasia present with variable phenotypes. Children with severe short stature and disproportion of the body segments usually have the mutation Asn540Lys. They respond to growth hormone (GH) therapy with an increase in spinal length and, coupled with a surgical leg-lengthening procedure, it is possible for some patients to achieve adult heights within the normal range. Some children who present with proportionate short stature and hypochondroplasia fail to increase their growth rate at puberty, although the growth spurt can be restored by GH therapy. Others, with an identical presentation, seem to grow normally during puberty. At present, there is no way of predicting who will undergo a normal pubertal growth spurt. We therefore monitor all patients during childhood and give GH treatment only to those patients who fail to develop a growth spurt at puberty. Severe cases may occasionally need treatment before puberty if their growth velocity is compromised, but these will probably also be candidates for a surgical leg-lengthening procedure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0803-5326
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-7
pubmed:dateRevised
2008-5-12
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Growth hormone therapy in hypochondroplasia.
pubmed:affiliation
London Centre for Paediatric Endocrinology, Middlesex Hospital, London, UK.
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't