Source:http://linkedlifedata.com/resource/pubmed/id/10100204
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-6-15
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pubmed:abstractText |
The effect of D1 and D2 dopamine receptor antagonists on the DNA-binding activity of the AP-1 transcription factor was studied in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medial forebrain bundle. In the caudate-putamen, vehicle-treated rats showed increased AP-1 DNA-binding activity, which appeared to be reversed completely by treatment with the D1 receptor antagonist SCH23390 (1 mg kg-1 i.p.) and partially by the D2 antagonist sulpiride (50 mg kg-1 i.p.). In the globus pallidus, vehicle and sulpiride did not induce AP-1, while SCH23390 increased it significantly. This induction was much more prominent in the 6-OHDA-lesioned hemisphere than in the intact hemisphere. The present study suggests that in the caudate-putamen, dopamine-depletion induces long-lasting enhancement of AP-1 DNA-binding activity via activation of D1 receptors and the simultaneous activation of D2 receptors facilitate it. However, in the globus pallidus of the 6-OHDA-lesioned hemisphere, D1 but not D2 antagonism induces AP-1 in certain cell populations which may be distinct from those expressing AP-1 upon stimulation of D2 receptors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0161-6412
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10100204-Animals,
pubmed-meshheading:10100204-Caudate Nucleus,
pubmed-meshheading:10100204-Corpus Striatum,
pubmed-meshheading:10100204-DNA-Binding Proteins,
pubmed-meshheading:10100204-Dopamine Antagonists,
pubmed-meshheading:10100204-Functional Laterality,
pubmed-meshheading:10100204-Globus Pallidus,
pubmed-meshheading:10100204-Male,
pubmed-meshheading:10100204-Oxidopamine,
pubmed-meshheading:10100204-Prosencephalon,
pubmed-meshheading:10100204-Putamen,
pubmed-meshheading:10100204-Rats,
pubmed-meshheading:10100204-Rats, Sprague-Dawley,
pubmed-meshheading:10100204-Receptors, Dopamine D1,
pubmed-meshheading:10100204-Receptors, Dopamine D2,
pubmed-meshheading:10100204-Transcription Factor AP-1
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pubmed:year |
1999
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pubmed:articleTitle |
Differential regulation of AP-1 DNA-binding activity by D1 and D2 dopamine receptor antagonists in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medial forebrain bundle.
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pubmed:affiliation |
Department of Neurology, Okayama University Medical School, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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