Linked Life Data

10100156

Source:http://linkedlifedata.com/resource/pubmed/id/10100156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-5-27
pubmed:abstractText
Birds have a maximum longevity (MLSP) much greater than mammals of similar metabolic rate and body size. Thus, they are ideal models to identify longevity characteristics not linked to low metabolic rates. In this investigation, we show that the fatty acid double bond content of total lipids and phosphatidylcholine, phosphatidylethanolamine and cardiolipin fractions of heart mitochondria is intrinsically lower in pigeons (MLSP = 35 years) than in rats (MLSP = 4 years). This is mainly due to a lower content of the most highly unsaturated docosahexaenoic acid (22:6n-3) and in some fractions arachidonic acid (20:4n-6). The lower double bond content leads to a lower sensitivity to in vitro lipid peroxidation, and is associated with a lower concentration of lipid peroxidation products in vivo, and a lower level of malondialdehyde-lysine protein adducts in heart mitochondria of pigeons than rats. These results, together with those previously obtained in other species or tissues, suggest that a low degree of fatty acid unsaturation is a general characteristic of longevous homeothermic vertebrate animals both when they have low metabolic rates (mammals of large body size) or high metabolic rates (small sized birds). This constitutive trait helps to protect their tissues and mitochondria against lipid peroxidation and oxidative protein modification and can be a factor contributing to their slow rate of aging. The results also show, for the first time in a physiological model, that lipid peroxidizability is related to lipoxidative protein damage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat.
pubmed:affiliation
Department of Basic Medical Sciences, Faculty of Medicine, Lleida University, Spain.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't