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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1977-3-15
|
| pubmed:abstractText |
The following five tyrosine-containing analogs of somatostatin (GIF) were synthesized by the solid-phase method: Tyr-GIF: [Tyr6]-GIF; [Tyr7]-GIF; [Tyr8]-GIF; [Tyr11]-GIF. These analogs except [Tyr8]-GIF were demonstrated to possess almost the same potency to inhibit thyrotropin release stimulated by thyrotropin-releasing hormone as that of synthesized GIF in vivo. [Tyr8]-GIF had potencies less than 0.5% of GIF. They also had the activity to inhibit Nembutal-induced growth hormone rise. The structure-activity relationship and availability of these analogs for radioimmunoassay were discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0013-7219
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
435-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1009896-Animals,
pubmed-meshheading:1009896-Growth Hormone,
pubmed-meshheading:1009896-Male,
pubmed-meshheading:1009896-Rats,
pubmed-meshheading:1009896-Somatostatin,
pubmed-meshheading:1009896-Structure-Activity Relationship,
pubmed-meshheading:1009896-Thyrotropin,
pubmed-meshheading:1009896-Tyrosine
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Biological activities of tyrosine-containing somatostatin analogs on inhibition of secretion of thyrotropin and growth hormone.
|
| pubmed:publicationType |
Journal Article
|