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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
4
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pubmed:dateCreated |
1999-5-24
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|
pubmed:abstractText |
Compounds were synthesized where oxygen in the ethoxypiperidine region of raloxifene is replaced with carbon, sulfur, or nitrogen linkages. Thia- and aza-substituted compounds were prepared by novel methodology. The compounds were evaluated in vitro as selective estrogen receptor modulators (SERMs). Calculations suggested the compounds exhibit an ER-alpha binding affinity/conformational energy relationship.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
22
|
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pubmed:volume |
9
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
523-8
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|
pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10098655-Binding, Competitive,
pubmed-meshheading:10098655-Carbon,
pubmed-meshheading:10098655-Cell Division,
pubmed-meshheading:10098655-Cell Line,
pubmed-meshheading:10098655-Crystallography, X-Ray,
pubmed-meshheading:10098655-Humans,
pubmed-meshheading:10098655-Oxygen,
pubmed-meshheading:10098655-Piperidines,
pubmed-meshheading:10098655-Raloxifene,
pubmed-meshheading:10098655-Receptors, Estrogen,
pubmed-meshheading:10098655-Structure-Activity Relationship
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|
pubmed:year |
1999
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|
pubmed:articleTitle |
Novel nonsteroidal selective estrogen receptor modulators. Carbon and heteroatom replacement of oxygen in the ethoxypiperidine region of raloxifene.
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pubmed:affiliation |
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
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pubmed:publicationType |
Journal Article
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