| pubmed-article:10096768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10096768 | lifeskim:mentions | umls-concept:C0011991 | lld:lifeskim |
| pubmed-article:10096768 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10096768 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10096768 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10096768 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:10096768 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10096768 | pubmed:dateCreated | 1999-5-13 | lld:pubmed |
| pubmed-article:10096768 | pubmed:abstractText | The role of nitric oxide (NO) on aloe-induced diarrhoea was studied in the rat. Nine hours after oral administration, aloe produced diarrhoea at doses of 5 g kg(-1)(20% rats with diarrhoea) and 20 g kg(-1) (100% of rats with diarrhoea). Lower doses of aloe (0.1 and 1 g kg(-1) did not produce a diarrhoeal response. Pre-treatment (i.p.) of rats with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME 2.5-25 mg kg(-1) reduced the diarrhoea induced by aloe (20 g kg(-1) 9 h after its oral administration. L-NAME (25 mg kg(-1)) also reduced the increase in faecal water excretion produced by aloe (20 g kg(-1). L-arginine (1500 mg kg(-1), i.p.), administered to rats pre-treated with L-NAME (25 mg kg(-1), drastically reduced the effect of L-NAME on diarrhoea and increase in faecal water excretion induced by aloe (20 g kg(-1). Given alone, L-arginine did not modify aloe-induced diarrhoea. Basal Ca2+ -dependent NO synthase activity in the rat colon was dose-dependently inhibited by aloe (0.1-20 g kg(-1)) and by aloin (0.1-1 g kg(-1)), the active ingredient of aloe. These results suggest that endogenous NO modulates the diarrhoeal effect of aloe. | lld:pubmed |
| pubmed-article:10096768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10096768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10096768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10096768 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10096768 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:10096768 | pubmed:author | pubmed-author:BorrelliFF | lld:pubmed |
| pubmed-article:10096768 | pubmed:author | pubmed-author:CapassoFF | lld:pubmed |
| pubmed-article:10096768 | pubmed:author | pubmed-author:SautebinLL | lld:pubmed |
| pubmed-article:10096768 | pubmed:author | pubmed-author:LongoRR | lld:pubmed |
| pubmed-article:10096768 | pubmed:author | pubmed-author:IzzoA AAA | lld:pubmed |
| pubmed-article:10096768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10096768 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:10096768 | pubmed:volume | 368 | lld:pubmed |
| pubmed-article:10096768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10096768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10096768 | pubmed:pagination | 43-8 | lld:pubmed |
| pubmed-article:10096768 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10096768 | pubmed:meshHeading | pubmed-meshheading:10096768... | lld:pubmed |
| pubmed-article:10096768 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10096768 | pubmed:articleTitle | The role of nitric oxide in aloe-induced diarrhoea in the rat. | lld:pubmed |
| pubmed-article:10096768 | pubmed:affiliation | Department of Experimental Pharmacology, University of Naples Federico II, Italy. | lld:pubmed |
| pubmed-article:10096768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10096768 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
