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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-13
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pubmed:abstractText |
The role of nitric oxide (NO) on aloe-induced diarrhoea was studied in the rat. Nine hours after oral administration, aloe produced diarrhoea at doses of 5 g kg(-1)(20% rats with diarrhoea) and 20 g kg(-1) (100% of rats with diarrhoea). Lower doses of aloe (0.1 and 1 g kg(-1) did not produce a diarrhoeal response. Pre-treatment (i.p.) of rats with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME 2.5-25 mg kg(-1) reduced the diarrhoea induced by aloe (20 g kg(-1) 9 h after its oral administration. L-NAME (25 mg kg(-1)) also reduced the increase in faecal water excretion produced by aloe (20 g kg(-1). L-arginine (1500 mg kg(-1), i.p.), administered to rats pre-treated with L-NAME (25 mg kg(-1), drastically reduced the effect of L-NAME on diarrhoea and increase in faecal water excretion induced by aloe (20 g kg(-1). Given alone, L-arginine did not modify aloe-induced diarrhoea. Basal Ca2+ -dependent NO synthase activity in the rat colon was dose-dependently inhibited by aloe (0.1-20 g kg(-1)) and by aloin (0.1-1 g kg(-1)), the active ingredient of aloe. These results suggest that endogenous NO modulates the diarrhoeal effect of aloe.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
368
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10096768-Aloe,
pubmed-meshheading:10096768-Animals,
pubmed-meshheading:10096768-Arginine,
pubmed-meshheading:10096768-Body Water,
pubmed-meshheading:10096768-Chelating Agents,
pubmed-meshheading:10096768-Defecation,
pubmed-meshheading:10096768-Diarrhea,
pubmed-meshheading:10096768-Dose-Response Relationship, Drug,
pubmed-meshheading:10096768-Egtazic Acid,
pubmed-meshheading:10096768-Enzyme Inhibitors,
pubmed-meshheading:10096768-Feces,
pubmed-meshheading:10096768-Male,
pubmed-meshheading:10096768-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:10096768-Nitric Oxide,
pubmed-meshheading:10096768-Nitric Oxide Synthase,
pubmed-meshheading:10096768-Plants, Medicinal,
pubmed-meshheading:10096768-Rats,
pubmed-meshheading:10096768-Rats, Wistar,
pubmed-meshheading:10096768-omega-N-Methylarginine
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pubmed:year |
1999
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pubmed:articleTitle |
The role of nitric oxide in aloe-induced diarrhoea in the rat.
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pubmed:affiliation |
Department of Experimental Pharmacology, University of Naples Federico II, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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