Linked Life Data

10096452

Source:http://linkedlifedata.com/resource/pubmed/id/10096452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-3-30
pubmed:abstractText
As an approach to clarifying the molecular basis of pain and fatigue in muscles involved in temporomandibular disorders, we examined the activity of histidine decarboxylase (HDC), the enzyme which forms histamine, in the masseter muscles of mice. In the resting muscle, HDC activity was very low. Direct electrical stimulation of the muscle markedly elevated HDC activity. HDC activity rose within 3 hrs of the electrical stimulation, peaked at 6 to 8 hrs, and then gradually declined. Intraperitoneal injection of a small amount of interleukin-1 (IL-1) (from 1 to 10 microg/kg) produced a similar elevation of HDC activity in the masseter muscle. We also examined the effect of an antihistamine, chlorphenylamine (CP), on temporomandibular disorders in humans and compared it with that of an anti-inflammatory analgesic, flurbiprofen (FB). Two groups received one or the other of the drugs daily for 7 days, and they were asked about their signs and symptoms before and after the treatment. A positive evaluation of their treatment was made by 74% of the CP group, but by only 48% of the FB group. Although the effects of CP on the limitation of mouth-opening and on joint noise were negligible, about 50% of the CP group answered positively concerning the drug's effect on spontaneous pain or pain induced by chewing or mouth-opening. The positive evaluation for CP (50%) in relieving associated symptoms (headache or shoulder stiffness) was significantly greater than for FB (13%). FB showed effectiveness similar to but sometimes weaker than that of CP on several symptoms. On the basis of these and previous results and the known actions of histamine, we propose that the histamine newly formed following the induction of HDC activity, which is itself mediated by IL-1, may be involved in inducing pain and, possibly, stiffness in muscles in temporomandibular disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-0345
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
769-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10096452-Adult, pubmed-meshheading:10096452-Analysis of Variance, pubmed-meshheading:10096452-Animals, pubmed-meshheading:10096452-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:10096452-Chlorpheniramine, pubmed-meshheading:10096452-Electric Stimulation, pubmed-meshheading:10096452-Facial Pain, pubmed-meshheading:10096452-Flurbiprofen, pubmed-meshheading:10096452-Histamine, pubmed-meshheading:10096452-Histamine H1 Antagonists, pubmed-meshheading:10096452-Histidine Decarboxylase, pubmed-meshheading:10096452-Humans, pubmed-meshheading:10096452-Injections, Intraperitoneal, pubmed-meshheading:10096452-Interleukin-1, pubmed-meshheading:10096452-Male, pubmed-meshheading:10096452-Masseter Muscle, pubmed-meshheading:10096452-Mice, pubmed-meshheading:10096452-Mice, Inbred BALB C, pubmed-meshheading:10096452-Muscle Fatigue, pubmed-meshheading:10096452-Single-Blind Method, pubmed-meshheading:10096452-Statistics, Nonparametric, pubmed-meshheading:10096452-Temporomandibular Joint Dysfunction Syndrome
pubmed:year
1999
pubmed:articleTitle
Possible involvement of histamine in muscular fatigue in temporomandibular disorders: animal and human studies.
pubmed:affiliation
Department of Geriatric Dentistry, School of Dentistry, Tohoku University, Sendai, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial, Research Support, Non-U.S. Gov't