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pubmed-article:10096020pubmed:abstractTextTip60, an HIV-1-Tat interactive protein, is a nuclear histone acetyltransferase (HAT) with unique histone substrate specificity. Since the acetylation of core histones at particular lysines mediates distinct effects on chromatin assembly and gene regulation, the identification of lysine site specificity of the HAT activity of Tip60 is an initial step in the analysis of its molecular function.lld:pubmed
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pubmed-article:10096020pubmed:articleTitleTip60 acetylates six lysines of a specific class in core histones in vitro.lld:pubmed
pubmed-article:10096020pubmed:affiliationDepartment of Cellular Biology, University of Tokyo, Japan.lld:pubmed
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