Linked Life Data

10095085

Source:http://linkedlifedata.com/resource/pubmed/id/10095085

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-5-13
pubmed:abstractText
Stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), a member of the MAP kinase (MAPK) superfamily, plays a key role in a variety of cellular processes. It is well established that SAPK/JNK activation is controlled by SEK1/MKK4, an up-stream MAP kinase kinase. To gain insight into the role of SEK1 during embryonic development and in adult life, we examined the temporal and spatial patterns of sek1 expression in mice by using in situ hybridization and immunohistochemical study. Dynamic changes of sek1 expression were observed during embryogenesis. Strong sek1 expression was detected in most of the central nervous system and in liver and thymus during early stages of development. While the sek1 expression in nervous system increases over time, expression in fetal liver and thymus gradually decreases as embryogenesis proceeds. High level of the sek1 expression in the central nervous system was persisted throughout postnatal development and remained at a stable level in adult brain. These observations provide an anatomical basis for the vital role(s) of SEK1 in development, for example, in hepatogenesis and/or neurogenesis. Although SEK1 was widely expressed in adult brain, more strong expression of the sek1 was observed at layers 2 and 6 in cerebral cortex, in Purkinje cells of cerebellum, and also in hypothalamic nuclei. The strongest expression of the sek1 was found in the CA3 region of hippocampus, the region being highly vulnerable to exitotoxicity-induced apoptosis in kainate-treated animal models. Interestingly, SEK1 was localized not only in cytoplasm but in dendrites and/or in nucleus of neurons depending on the regions of adult mouse brain. Taken together, these results suggest multiple roles of the SEK1 during embryogenesis and in adult brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0169-328X
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Elsevier Science B. V.
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-40
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10095085-Age Factors, pubmed-meshheading:10095085-Animals, pubmed-meshheading:10095085-Apoptosis, pubmed-meshheading:10095085-Brain Chemistry, pubmed-meshheading:10095085-Brain Stem, pubmed-meshheading:10095085-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:10095085-Dendrites, pubmed-meshheading:10095085-Female, pubmed-meshheading:10095085-Gene Expression Regulation, Developmental, pubmed-meshheading:10095085-Gene Expression Regulation, Enzymologic, pubmed-meshheading:10095085-Hippocampus, pubmed-meshheading:10095085-Hypothalamus, pubmed-meshheading:10095085-In Situ Hybridization, pubmed-meshheading:10095085-Liver, pubmed-meshheading:10095085-MAP Kinase Kinase 4, pubmed-meshheading:10095085-Mice, pubmed-meshheading:10095085-Mice, Inbred BALB C, pubmed-meshheading:10095085-Mitogen-Activated Protein Kinase Kinases, pubmed-meshheading:10095085-Mitogen-Activated Protein Kinases, pubmed-meshheading:10095085-Neurons, pubmed-meshheading:10095085-Pregnancy, pubmed-meshheading:10095085-Protein Kinases, pubmed-meshheading:10095085-Thymus Gland, pubmed-meshheading:10095085-p38 Mitogen-Activated Protein Kinases
pubmed:year
1999
pubmed:articleTitle
Dynamic expression of SEK1 suggests multiple roles of the gene during embryogenesis and in adult brain of mice.
pubmed:affiliation
Department of Anatomy, Inha University Medical School, Inchon, 402-751, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't