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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-25
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pubmed:abstractText |
Insulin-like growth factor 1 (IGF-1) plays a critical role in CNS development. IGF-1 can block neuronal apoptosis in vitro and in vivo. IGF-1 is thought to be cleaved into des-N-(1-3)-IGF-1 and an amino terminal glycine-proline-glutamate (GPE tripeptide). Here we report a neuroprotective role for GPE tripeptide, with enhanced survival of the CA1-2 hippocampal neurons following an excitotoxic insult in vitro. Binding and displacement studies suggest uniquely distributed sites of action within the rat including the hippocampal CA1-2, pyriform cortex, amygdala, choroid plexus, blood vessels and to a lesser extent in the cortical regions. A similar pattern of binding was seen in the human. This finding could lead to new strategies to reduce neuronal death after injury and in disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0959-4965
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pubmed:author |
pubmed-author:BenattiLL,
pubmed-author:CuratoloLL,
pubmed-author:DragunowMM,
pubmed-author:FaullR LRL,
pubmed-author:GattoII,
pubmed-author:GluckmanP DPD,
pubmed-author:GuanJJ,
pubmed-author:PeetersCC,
pubmed-author:PostCC,
pubmed-author:SauraJJ,
pubmed-author:SkinnerS JSJ,
pubmed-author:WilliamsC ECE
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10094155-Animals,
pubmed-meshheading:10094155-Autoradiography,
pubmed-meshheading:10094155-Binding Sites,
pubmed-meshheading:10094155-Cell Survival,
pubmed-meshheading:10094155-Hippocampus,
pubmed-meshheading:10094155-Humans,
pubmed-meshheading:10094155-Insulin-Like Growth Factor I,
pubmed-meshheading:10094155-Neurons,
pubmed-meshheading:10094155-Neuroprotective Agents,
pubmed-meshheading:10094155-Oligopeptides,
pubmed-meshheading:10094155-Organ Culture Techniques,
pubmed-meshheading:10094155-Rats
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pubmed:year |
1999
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pubmed:articleTitle |
Neuroprotective effects of Gly-Pro-Glu, the N-terminal tripeptide of IGF-1, in the hippocampus in vitro.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, University of Auckland, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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