Source:http://linkedlifedata.com/resource/pubmed/id/10091711
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1999-5-24
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pubmed:abstractText |
We report a general method for the synthesis of mycalazol 11 and some related 5-acyl-2-hydroxymethylpyrroles using a Stille coupling of 5-(tri-n-butylstannyl)pyrrole-2-carboxaldehyde with an acid chloride as the key step. The newly prepared 5-acyl-2-hydroxymethylpyrroles 5-7, together with the 5-carboxamido-2-hydroxymethylpyrrole 10, have been assayed for in vitro cytotoxicity against the P388 murine leukemia cell line.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
505-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10091711-Animals,
pubmed-meshheading:10091711-Antineoplastic Agents,
pubmed-meshheading:10091711-Drug Screening Assays, Antitumor,
pubmed-meshheading:10091711-Leukemia P388,
pubmed-meshheading:10091711-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10091711-Mice,
pubmed-meshheading:10091711-Pyrroles
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pubmed:year |
1999
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pubmed:articleTitle |
The synthesis and P388 cytotoxicity of mycalazol 11 and related 5-acyl-2-hydroxymethylpyrroles.
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pubmed:affiliation |
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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