Source:http://linkedlifedata.com/resource/pubmed/id/10091686
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1999-5-24
|
| pubmed:abstractText |
Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
369-74
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:10091686-Animals,
pubmed-meshheading:10091686-Antineoplastic Agents,
pubmed-meshheading:10091686-Depsipeptides,
pubmed-meshheading:10091686-Drug Screening Assays, Antitumor,
pubmed-meshheading:10091686-Humans,
pubmed-meshheading:10091686-Mice,
pubmed-meshheading:10091686-Peptides, Cyclic,
pubmed-meshheading:10091686-Tumor Cells, Cultured
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region).
|
| pubmed:affiliation |
Lilly Research Laboratories, A Division of Eli Lilly and Co., Indianapolis, IN 46285, USA.
|
| pubmed:publicationType |
Journal Article
|