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pubmed:abstractText |
Nitric oxide (NO), cGMP, and cAMP affect the synthesis, metabolism, and cellular effects each other. We wanted to study how cGMP and cAMP interact to affect the induced synthesis of NO in response to interleukin-1 beta (IL-1 beta) in rat pulmonary artery smooth muscle cells. To further dissect the relative contributions of each cyclic nucleotide, and to detect any possible "crossover" effect of one cyclic nucleotide activating the other protein kinase, we tested how pharmacological inhibition of cGMP-dependent and cAMP-dependent protein kinases (PKG and PKA, respectively) affected responses.
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pubmed:affiliation |
Section of Pediatric Surgery and the Department of Surgery, University of North Carolina at Chapel Hill, C.B. 7210, 3010 Old Clinics Building, Chapel Hill, North Carolina, 27599-7210, USA.
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