Source:http://linkedlifedata.com/resource/pubmed/id/10090783
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
A range of (2,2':6',2''-terpyridine)platinum(II) complexes are shown to possess antiprotozoal activity in vitro against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei,the causative organisms of tropical diseases leishmaniasis and trypanosomiasis. The best compounds caused 100% and 78% inhibition of growth of the intracellular amastigote forms of L. donovani and T. cruzi, respectively, at a concentration of 1 microM and 100% inhibition of growth of the bloodstream trypomastigote forms of T. brucei at a concentration of 0.03 microM. The results obtained with complexes in which the fourth ligand to platinum(II) is capable of being substituted with a substitution inert hydroxyethanethiolate complex are compared. The ammine complexes show high antiprotozoal activity suggesting that the trans influence of the 2,2':6',2''-terpyridine ligand has a profound effect on the ease of displacement of the fourth ligand in (2,2':6',2'' -terpyridine)platinum(II) complexes, although nonbonded interaction between the ammine ligand and the 6 and 6' ' hydrogens probably also weakens the ligation to Pt(II).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
999-1006
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10090783-Animals,
pubmed-meshheading:10090783-Intercalating Agents,
pubmed-meshheading:10090783-Leishmania donovani,
pubmed-meshheading:10090783-Organoplatinum Compounds,
pubmed-meshheading:10090783-Pyridines,
pubmed-meshheading:10090783-Trypanocidal Agents,
pubmed-meshheading:10090783-Trypanosoma brucei brucei,
pubmed-meshheading:10090783-Trypanosoma cruzi
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pubmed:year |
1999
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pubmed:articleTitle |
Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei.
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pubmed:affiliation |
Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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