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pubmed-article:10088173pubmed:abstractTextA synopsis of the many aspects and factors that contribute to renal tubulo-interstitial fibrosis is presented. The role of fibrogenic cytokines and the conversion of fibroblasts to myofibroblasts are described. It is emphasized that oxygen radicals cause fibroblasts to generate collagen. The properties of those accessory modulatory proteins that affect the behavior of cells in the interstitium are considered and how matrix for ensuing fibrosis is laid down. Understanding the extracellular matrix proteins and these modulatory proteins is important because their behavior can now be modified by means of antisense oligonucleotides.lld:pubmed
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pubmed-article:10088173pubmed:articleTitleModulatory proteins and processes in alliance with immune cells, mediators, and extracellular proteins in renal interstitial fibrosis.lld:pubmed
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