Linked Life Data

10088162

Source:http://linkedlifedata.com/resource/pubmed/id/10088162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-6-24
pubmed:abstractText
In this study, we evaluated the efficacy of bone marrow immunoscintigraphy (BMIS) for the detection of skeletal metastases in 23 patients with histologically confirmed breast cancer. All patients underwent whole-body BMIS 3-6 h after the intravenous injection of 0.20-0.33 mg of the intact anti-NCA 95 MAb BW 250/183 labelled with 259-555 MBq 99Tcm and a whole-body 99Tcm-MDP bone scan. In four patients, BMIS SPET of the lumbar spine was also performed. Serum alkaline phosphatase was determined in all patients and the level of human anti-mouse antibody (HAMA) in 16. Final diagnosis was confirmed by radiology and 2 years follow-up. Compared with the 99Tcm-MDP bone scan, BMIS demonstrated better specificity (88% vs 75%) and a better positive predictive value (92% vs 85%). There were no significant differences between BMIS and the bone scan in the detection of skeletal metastases (P > 0.05). In one patient with normal planar BMIS of the lumbar spine, SPET disclosed a metastatic lesion in the bone marrow. The correlation coefficient between BMIS and bone scan and between BMIS and serum alkaline phosphatase was r = 0.688 and r = 0.483 respectively. One patient developed a minor HAMA response after BMIS. Patients with diffuse increased activity of the skull on the bone scan had a significantly higher skull to whole body ratio on BMIS (P < 0.01). Thus BMIS can improve the specificity and positive predictive value of bone scanning in the detection of skeletal metastases, with a low HAMA response. Diffuse increased activity of the skull on bone scans could be explained by bone marrow extension. SPET scanning of the spine may improve the sensitivity of BMIS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0143-3636
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10088162-Adult, pubmed-meshheading:10088162-Aged, pubmed-meshheading:10088162-Antibodies, Monoclonal, pubmed-meshheading:10088162-Antigens, Neoplasm, pubmed-meshheading:10088162-Bone Marrow, pubmed-meshheading:10088162-Bone Marrow Neoplasms, pubmed-meshheading:10088162-Bone Neoplasms, pubmed-meshheading:10088162-Breast Neoplasms, pubmed-meshheading:10088162-Cell Adhesion Molecules, pubmed-meshheading:10088162-Female, pubmed-meshheading:10088162-Humans, pubmed-meshheading:10088162-Lumbosacral Region, pubmed-meshheading:10088162-Membrane Glycoproteins, pubmed-meshheading:10088162-Middle Aged, pubmed-meshheading:10088162-Radioimmunodetection, pubmed-meshheading:10088162-Radiopharmaceuticals, pubmed-meshheading:10088162-Sensitivity and Specificity, pubmed-meshheading:10088162-Technetium Tc 99m Medronate, pubmed-meshheading:10088162-Tomography, Emission-Computed, pubmed-meshheading:10088162-Whole-Body Counting
pubmed:year
1999
pubmed:articleTitle
Bone marrow immunoscintigraphy for the detection of skeletal metastases in patients with breast cancer.
pubmed:affiliation
Department of Oncology and Nuclear Medicine, University Hospital Sestre Milosrdnice, Zagreb, Croatia. MiodragLacic@public.srce.hr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't