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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-5-28
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pubmed:abstractText |
The novel marine terpenoid dehydrothyrsiferol (DHT) has been isolated from a Canarian red alga Laurencia viridis sp. nov (Ceramiales, Rhodomelaceae) (1). Its cytotoxicity against three human breast cancer cell lines, namely T47D, ZR-75-1, and Hs578T was examined and compared with the chemotherapeutic compound doxorubicin and the mitosis-inhibitor colchicine. Primary breast carcinomas exhibit MDR1 gene expression (3). As the investigated mammary cell lines did not exhibit rhodamine 123 efflux we proved in a P-glycoprotein (Pgp) overexpressing human epidermoid cancer cell line that the marine metabolite does not modulate Pgp mediated drug transport. Therefore, it could be used in Pgp expressing cancer cells without interference.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1019-6439
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
739-43
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10087323-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10087323-Biological Transport,
pubmed-meshheading:10087323-Breast Neoplasms,
pubmed-meshheading:10087323-Cell Division,
pubmed-meshheading:10087323-Dose-Response Relationship, Drug,
pubmed-meshheading:10087323-Drug Screening Assays, Antitumor,
pubmed-meshheading:10087323-Eukaryota,
pubmed-meshheading:10087323-Fluorescent Dyes,
pubmed-meshheading:10087323-Humans,
pubmed-meshheading:10087323-KB Cells,
pubmed-meshheading:10087323-Marine Biology,
pubmed-meshheading:10087323-P-Glycoproteins,
pubmed-meshheading:10087323-Pyrans,
pubmed-meshheading:10087323-Rhodamine 123,
pubmed-meshheading:10087323-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Division of Special Gynecology, University of Vienna, AKH/EBO 5Q, A-1090 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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