Linked Life Data

1008515

Source:http://linkedlifedata.com/resource/pubmed/id/1008515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-2-24
pubmed:abstractText
Two high affinity saturable binding components were observed in the cytosol of hyperplastic human prostate gland using glyceroltris graident centrifugations having a sedimentation coefficient of 8-10 S and 4-5 S. Binding experiments with different steroids indicate that they correspond to the androgen-receptor protein on one hand and to sex steroid binding plasma protein (SBP) on the other hand. The calculated cytosol receptor concentration was 50 fentomoles/mg protein or 5,000 wites per cell. The SBP concentration, measured by equilibrium dialysis, indicated 8,000 sites per cell which represent 5% of the SBP concentration in the corresponding plasma. Prostate samples were submitted to constant flow organ culture in the presence of 3H-testosterone and increasing amounts of human serum albumin (HSA) and/or SBP. The uptake and metabolism of testosterone were measured and the results suggest that the SBP-testosterone complex could be associated with the prostate cells.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4266
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Androgen binding proteins in human prostate (author's transl)].
pubmed:publicationType
Journal Article, English Abstract