Linked Life Data

10084246

Source:http://linkedlifedata.com/resource/pubmed/id/10084246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-3-29
pubmed:abstractText
The occurrence of epileptic seizures during onchocercal infestation has been suspected. Epidemiologic studies are necessary to confirm the relation between onchocerciasis and epilepsy. A matched case-control study was conducted in dispensaries of three northwestern towns of the Central African Republic. Each epileptic case was matched against two nonepileptic controls on the six criteria of sex, age (+/-5 years), residence, treatment with ivermectin, date of last ivermectin dose, and the number of ivermectin doses. Onchocerciasis was defined as at least one microfilaria observed in iliac crest skin snip biopsy. A total of 561 subjects (187 cases and 374 controls) were included in the study. Of the epileptics, 39.6% had onchocerciasis, as did 35.8% of the controls. The mean dermal microfilarial load was 26 microfilariae per mg of skin (standard deviation, 42) in the epileptics and 24 microfilariae per mg of skin (standard deviation, 48) in the controls. This matched case-control study found some relation (odds ratio = 1.21, 95% confidence interval 0.81-1.80), although it was nonstatistically significant.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Africa, http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/CENTRAL NERVOUS SYSTEM, http://linkedlifedata.com/resource/pubmed/keyword/Central African Republic, http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/French Speaking Africa, http://linkedlifedata.com/resource/pubmed/keyword/Measurement, http://linkedlifedata.com/resource/pubmed/keyword/Middle Africa, http://linkedlifedata.com/resource/pubmed/keyword/ONCHOCERCIASIS, http://linkedlifedata.com/resource/pubmed/keyword/PARASITIC DISEASES, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Prevalence, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Research Report
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9262
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
565-70
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: Epileptic seizures are frequent in neurocysticercosis and may occur during cerebral malaria. Findings are reported from a matched case-control study conducted in March 1996 in the savannah woodland region of northwest Central African Republic to determine whether any relation exists between Onchocerca volvulus infestation and epilepsy. About 70% of the study region's inhabitants are infested with O. volvulus. Each epileptic case was matched against 2 nonepileptic controls on the criteria of sex, age, residence, treatment with ivermectin, date of last ivermectin dose, and the number of ivermectin doses. Onchocerciasis was defined as at least 1 microfilaria observed in iliac crest skin snip biopsy. 187 cases and 374 controls were included in the study. 39.6% of the epileptics and 35.8% of the controls had onchocerciasis. The mean dermal microfilarial load was 26 microfilariae per mg of skin in the epileptics and 24 microfilariae per mg of skin in the controls. The relation between O. volvulus infestation and epilepsy was statistically nonsignificant.
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Onchocerciasis and epilepsy: a matched case-control study in the Central African Republic.
pubmed:affiliation
Institute of Epidemiology and Tropical Neurology, Faculty of Medicine, Limoges, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't