Linked Life Data

10084096

Source:http://linkedlifedata.com/resource/pubmed/id/10084096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-5-6
pubmed:abstractText
This double-blind, randomized trial compared the onset of sedation with two patient-controlled sedation regimens, allowing a maximum of 16 or 25 mg min-1 propofol. Forty fit young patients presenting for elective surgery were asked to try to put themselves to sleep using the system. Onset times of sedative effect, slurred speech and amnesia were recorded. All patients achieved satisfactory sedation, and none became oversedated. Patients receiving 16 mg min-1 propofol were not reliably sedated within 5 min and took significantly longer to develop slurred speech and amnesia (P < 0.01 for both). We conclude that this maximum infusion rate does not produce amnesia or sedation rapidly enough to be clinically useful. A maximum infusion rate of 25 mg min-1 allowed rapid sedation in all patients without oversedation and may be an acceptable compromise between efficacy and safety.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0265-0215
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-22
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Patient-controlled sedation using propofol: randomized, double-blind dose refinement.
pubmed:affiliation
Department of Anaesthesia, Royal Oldham Hospital, Lancashire, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial