Source:http://linkedlifedata.com/resource/pubmed/id/10082504
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
1999-4-13
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| pubmed:abstractText |
Sodium-lithium countertransport (Na-Li CT) activity in red blood cells relates cross-sectionally and longitudinally to blood pressure and hypertension. Lifestyle and metabolic factors relate cross-sectionally to this sodium transporter. The aim of this study was to conduct a prospective analysis of 6-year Na-Li CT change and of traits related to Na-Li CT change. In 2183 participants in the Gubbio Population Study (972 men and 1211 women; baseline ages, 18 to 74 years), the following data collected at baseline and 6-year follow-up were analyzed: Na-Li CT; gender; age; body mass index (BMI); blood pressure; antihypertensive treatment; alcohol intake; smoking habits; urinary sodium-to-potassium ratio; and plasma cholesterol, glucose, uric acid, sodium, potassium, and triglycerides (measured only at follow-up). Six-year changes were defined as follow-up minus baseline values. Na-Li CT was higher at follow-up than at baseline in both genders (P<0.001). Baseline Na-Li CT; baseline and change values of BMI; and change values of alcohol intake, plasma potassium, and plasma glucose related to Na-Li CT change significantly and independently with control for other variables. Follow-up plasma triglyceride levels also related independently to Na-Li CT change. Coefficients were positive for BMI, alcohol intake, and plasma glucose and triglyceride levels and were negative for baseline Na-Li CT and plasma potassium levels. Baseline and change values of other variables did not relate significantly to Na-Li CT change. In conclusion, in prospective analyses, BMI, alcohol intake, plasma glucose, and lipids were directly related to Na-Li CT change; baseline Na-Li CT and plasma potassium levels were inversely related. The data support the concept that lifestyle and related metabolic factors influence Na-Li CT.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiporters,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-lithium countertransporter
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0194-911X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
887-93
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10082504-Adolescent,
pubmed-meshheading:10082504-Adult,
pubmed-meshheading:10082504-Aged,
pubmed-meshheading:10082504-Aging,
pubmed-meshheading:10082504-Alcohol Drinking,
pubmed-meshheading:10082504-Antiporters,
pubmed-meshheading:10082504-Body Mass Index,
pubmed-meshheading:10082504-Cholesterol,
pubmed-meshheading:10082504-Female,
pubmed-meshheading:10082504-Humans,
pubmed-meshheading:10082504-Lithium,
pubmed-meshheading:10082504-Male,
pubmed-meshheading:10082504-Middle Aged,
pubmed-meshheading:10082504-Multivariate Analysis,
pubmed-meshheading:10082504-Prospective Studies,
pubmed-meshheading:10082504-Regression Analysis,
pubmed-meshheading:10082504-Sodium,
pubmed-meshheading:10082504-Time Factors,
pubmed-meshheading:10082504-Triglycerides
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| pubmed:year |
1999
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| pubmed:articleTitle |
Prospective analysis of traits related to 6-year change in sodium-lithium countertransport. Gubbio Population Study Research Group.
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| pubmed:affiliation |
Division of Nephrology, Second Medical School, Naples University, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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