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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5409
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
Activity shapes the structure of neurons and their circuits. Two-photon imaging of CA1 neurons expressing enhanced green fluorescent protein in developing hippocampal slices from rat brains was used to characterize dendritic morphogenesis in response to synaptic activity. High-frequency focal synaptic stimulation induced a period (longer than 30 minutes) of enhanced growth of small filopodia-like protrusions (typically less than 5 micrometers long). Synaptically evoked growth was long-lasting and localized to dendritic regions close (less than 50 micrometers) to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors. Thus, synaptic activation can produce rapid input-specific changes in dendritic structure. Such persistent structural changes could contribute to the development of neural circuitry.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1923-7
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:10082466-2-Amino-5-phosphonovalerate,
pubmed-meshheading:10082466-Animals,
pubmed-meshheading:10082466-Culture Techniques,
pubmed-meshheading:10082466-Dendrites,
pubmed-meshheading:10082466-Electric Stimulation,
pubmed-meshheading:10082466-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10082466-Green Fluorescent Proteins,
pubmed-meshheading:10082466-Hippocampus,
pubmed-meshheading:10082466-Luminescent Proteins,
pubmed-meshheading:10082466-Microscopy,
pubmed-meshheading:10082466-Morphogenesis,
pubmed-meshheading:10082466-Pseudopodia,
pubmed-meshheading:10082466-Pyramidal Cells,
pubmed-meshheading:10082466-Rats,
pubmed-meshheading:10082466-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10082466-Sindbis Virus,
pubmed-meshheading:10082466-Synapses,
pubmed-meshheading:10082466-Synaptic Membranes,
pubmed-meshheading:10082466-Synaptic Transmission
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pubmed:year |
1999
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pubmed:articleTitle |
Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity.
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pubmed:affiliation |
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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