|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1999-4-19
|
|
pubmed:abstractText |
We have previously shown that treatment by anticancer drugs sensitized tumor cells to Fas (APO-1/CD95)-mediated cell death. The present study demonstrates that the cytotoxic drugs cisplatin, doxorubicin and mitomycin C induce the accumulation of the Fas receptor, the FADD adaptor molecule, the procaspases-8, -3 and -2L and the proapoptotic molecule Bax in several human colon cancer cells. This upregulation is also observed in U3A myeloblastoma cells that do not express STAT-1, a transcription factor involved in the constitutive expression of procaspases. We conclude that anticancer drugs sensitize tumor cells to Fas-mediated cell death by a STAT-1-independent upregulation of molecules involved in this apoptotic pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dactinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/FADD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas-Associated Death Domain Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Mitomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
24
|
|
pubmed:volume |
256
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
603-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10080945-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10080945-Antigens, CD95,
pubmed-meshheading:10080945-Antineoplastic Agents,
pubmed-meshheading:10080945-Apoptosis,
pubmed-meshheading:10080945-Carrier Proteins,
pubmed-meshheading:10080945-Caspase 2,
pubmed-meshheading:10080945-Caspase 3,
pubmed-meshheading:10080945-Caspase 8,
pubmed-meshheading:10080945-Caspase 9,
pubmed-meshheading:10080945-Caspases,
pubmed-meshheading:10080945-Cisplatin,
pubmed-meshheading:10080945-Colonic Neoplasms,
pubmed-meshheading:10080945-DNA-Binding Proteins,
pubmed-meshheading:10080945-Dactinomycin,
pubmed-meshheading:10080945-Doxorubicin,
pubmed-meshheading:10080945-Enzyme Precursors,
pubmed-meshheading:10080945-Fas-Associated Death Domain Protein,
pubmed-meshheading:10080945-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10080945-Humans,
pubmed-meshheading:10080945-Isoenzymes,
pubmed-meshheading:10080945-Mitomycin,
pubmed-meshheading:10080945-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:10080945-Proto-Oncogene Proteins,
pubmed-meshheading:10080945-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10080945-RNA, Messenger,
pubmed-meshheading:10080945-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10080945-STAT1 Transcription Factor,
pubmed-meshheading:10080945-Trans-Activators,
pubmed-meshheading:10080945-Transcription, Genetic,
pubmed-meshheading:10080945-Tumor Cells, Cultured,
pubmed-meshheading:10080945-Up-Regulation,
pubmed-meshheading:10080945-bcl-2-Associated X Protein
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs.
|
|
pubmed:affiliation |
Department of Biology and Therapy of Cancer (JE 515), Faculty of Medicine and Pharmacy, 7 boulevard Jeanne d'Arc, Dijon Cédex, 21033, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
