Linked Life Data

10080181

Source:http://linkedlifedata.com/resource/pubmed/id/10080181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-3-31
pubmed:abstractText
The mammalian cochlea contains an invariant mosaic of sensory hair cells and non-sensory supporting cells reminiscent of invertebrate structures such as the compound eye in Drosophila melanogaster. The sensory epithelium in the mammalian cochlea (the organ of Corti) contains four rows of mechanosensory hair cells: a single row of inner hair cells and three rows of outer hair cells. Each hair cell is separated from the next by an interceding supporting cell, forming an invariant and alternating mosaic that extends the length of the cochlear duct. Previous results suggest that determination of cell fates in the cochlear mosaic occurs via inhibitory interactions between adjacent progenitor cells (lateral inhibition). Cells populating the cochlear epithelium appear to constitute a developmental equivalence group in which developing hair cells suppress differentiation in their immediate neighbours through lateral inhibition. These interactions may be mediated through the Notch signalling pathway, a molecular mechanism that is involved in the determination of a variety of cell fates. Here we show that genes encoding the receptor protein Notch1 and its ligand, Jagged 2, are expressed in alternating cell types in the developing sensory epithelium. In addition, genetic deletion of Jag2 results in a significant increase in sensory hair cells, presumably as a result of a decrease in Notch activation. These results provide direct evidence for Notch-mediated lateral inhibition in a mammalian system and support a role for Notch in the development of the cochlear mosaic.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1061-4036
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10080181-Animals, pubmed-meshheading:10080181-Calcium-Binding Proteins, pubmed-meshheading:10080181-Carrier Proteins, pubmed-meshheading:10080181-Cell Differentiation, pubmed-meshheading:10080181-Cochlea, pubmed-meshheading:10080181-Embryonic Induction, pubmed-meshheading:10080181-Female, pubmed-meshheading:10080181-Gene Expression Regulation, Developmental, pubmed-meshheading:10080181-Hair Cells, Auditory, Outer, pubmed-meshheading:10080181-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:10080181-Male, pubmed-meshheading:10080181-Mammals, pubmed-meshheading:10080181-Membrane Proteins, pubmed-meshheading:10080181-Mice, pubmed-meshheading:10080181-Mice, Mutant Strains, pubmed-meshheading:10080181-Morphogenesis, pubmed-meshheading:10080181-Mutation, pubmed-meshheading:10080181-Organ of Corti, pubmed-meshheading:10080181-Pregnancy, pubmed-meshheading:10080181-Proteins, pubmed-meshheading:10080181-Receptor, Notch1, pubmed-meshheading:10080181-Receptors, Cell Surface, pubmed-meshheading:10080181-Signal Transduction, pubmed-meshheading:10080181-Transcription Factors
pubmed:year
1999
pubmed:articleTitle
Notch signalling pathway mediates hair cell development in mammalian cochlea.
pubmed:affiliation
Department of Cell Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't